黄芪注射液治疗慢性活动性肝炎的临床与实验研究

本文旨在探讨黄芪注射液在慢性活动性肝炎(CAH)中的临床疗效及应用价值。121例CAH住院患者随机分为治疗组和对照组,治疗组用黄芪注射液肌注,每日2次;对照组用垂盆草冲剂,每日3次。两组均以2个月为一疗程。结果显示:两组临床症状、体征的改善无差异(P>0.05),而治疗组的临床总有效率明显高于对照组(P<0.05),HDeAg转阴率明显高于对照组(P<0.01);治疗组IgG和补体C_3明显下降。提示黄芪注射液在促进肝细胞功能恢复的同时,调整和改善了机体的细胞免疫、体液免疫水平。

Clinical and laboratory studies on treating chronic active hepatitis with Inj. Radix Astragali

The aim of this article is to determine the efficacy and practical value of Inj. Radix Astragali in the treatment of chronic active hepatitis(CAH). 121 patients with CAH were allocated randomly into treatment and control groups. The patients in the treatment group received Inj. Radix Astragali intramuscularly bid and patients in control group received Chui-Peng-Cao granules orally tid. The duration of a course of treatment is 2 months in both groups. The result showed that the improvement in signs and symptoms did not differ significantly between 2 groups(P>0. 05). However,the global response rate and HBeA seroconversion rate in the treatment group were significantly higher than those in the control group(P<0. 01 ,respectively). IgG and complement C levels decreased significanlly in the treatment group. The results suggeste that Inj. Radix Astragali not only enhanced the recovery of liver cell functions but also improved cellular and humoral immunization of the individuals.