厄贝沙坦与厄贝沙坦／氢氯噻嗪复方制齐佾疗轻中度原发性高血压的疗效对比观察

目的评价厄贝沙坦与厄贝沙坦／氢氯噻嗪复方制剂治疗高血压病的疗效。方法轻中度原发性高血压患者共106例，随机分为两组，一组为厄贝沙坦治疗组（n=52），服用厄贝沙坦150mg，1次／日；另一组为厄贝沙坦／氢氯噻嗪复方制剂组（n=54），服用厄贝沙坦150rng和氢氯噻嗪12．5mg的复方制剂，1次／日。结果治疗12周后．厄贝沙坦／氢氯噻嗪复方制剂降压的总有效率为83．3％（45／54），厄贝沙坦降压的总有效率为78．8％（41／52），两组血钾、LDL-C、血糖较入组时无明显变化，组间差异无统计学意义，未观察到严重不良反应。结论厄贝沙坦／氢氯噻嗪复方制剂治疗轻中度原发性高血压患者的控制率和达标率较高．较单用厄贝沙坦未增加不良反府．

The efficacy comparation of irbesartan and irbesartan/hydrochlorothiazide compound in the treatment of mild to moderate essential hypertension

Objective To evaluate the efficacy of irbesartan and irbesartan/hydrochlorothiazide compound in the treatment of hypertension.Methods One hundred and six cases of mild to moderate essential hypertension patients were randomly di vided into two groups,a group of irbesartan treatment group(n = 52),with irbesartan 150 mg daily;another is irbesartan/hydrochlorothiazide compound treatment group(n = 54),with irbesartan 150 mg and hydrochlorothiazide thiazide 12.5 mg daily.Results After 12 weeks of treatment,total effective rate of irbesartan/hydrochlorothiazide compound treatment group was 83.3%(45/54),and the total effective rate of irbesartan treatment group was 78.8%(41/52),there were no significant dif ference on potassium,LDL-C,blood glucose before and after treatment in either group,and there was no significant differ ence and no serious adverse reactions between two groups.Conclusion It can obtain a higher control rate and compliance rate that using irbesartan and hydrochlorothiazide tablets than irbesartan in treatment of mild to moderate essential hyper tension,and with no increase in adverse reactions.