| Expression of LL-37, Human beta Defensin-2, and CCR6 mRNA in Patients with Psoriasis Vuigaris |
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| 作者姓名： | 李东升 李家文 段逸群 周小勇 |
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| 作者单位： | Department of Dermatology，the First Hospital of Wuhan，Department of Dermatology，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Department of Dermatology，the First Hospital of Wuhan，Department of Dermatology，the First Hospital of Wuhan Wuhan 430022，China，Wuhan 430022，China，Wuhan 430022，China，Wuhan 430022，China |
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| 摘 要： | Theinnateimmunesystemofhumanskincon tainsantimicrobial peptidesknownascathelicidins(LL 37)andhumanbeta defensins (hBD) 1] .Innor malskinthesepeptidesarenegligible ,buttheexpres sionofthemwillbetriggeredbyinjuryorinflamma tionoftheskin .Andtheirexpression…
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| 关 键 词： | LL-37 基因表达 β防御素-2 CCR6 mRNA 牛皮癣 hBD-2 |
| 收稿时间： | 1 December 2003 |
Expression of LL-37, human beta defensin-2, and CCR6 mRNA in patients with psoriasis vulgaris |
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| Li?Dongsheng,Li?Jiawen,Duan?Yiqun,Zhou?Xiaoyong.Expression of LL-37, Human beta Defensin-2, and CCR6 mRNA in Patients with Psoriasis Vuigaris[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2004,24(4):404-406. |
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| Authors: | Li Dongsheng Li Jiawen Duan Yiqun Zhou Xiaoyong |
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| Institution: | 1. Department of Dermatology, the First Hospital of Wuhan, Wuhan 430022, China
2. Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China |
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| Abstract: | To investigate whether LL-37 and human beta defensin-2 (hBD-2) is related to the patients with psoriasis seldom having skin infections and explore the role of the two peptides and CCR6 (the receptor of hBD-2) in the pathogenesis of psoriasis, the expression levels of mRNA of LL-37, hBD-2, and CCR6 in skin lesions of patients with psoriasis vulgaris were detected by using RT-PCR. The results showed that the mRNA expression levels of the two peptides and CCR6 in psoriatic lesions all increased compared with the normal skin (P<0.001). It was suggested that up-regulated expression of LL-37 and hBD-2 might be the main reason that result in the the skin of patients with psoriasis being seldom infected, and the two peptides and CCR6 might play crucial roles in the pathogenesis of psoriasis. |
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| Keywords: | psoriasis LL-37 human beta Defensin-2 CCR6 |
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