Anidulafungin: a new echinocandin for candidal infections |
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Authors: | de la Torre Pola Reboli Annette C |
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Affiliation: | University of Medicine and Dentistry of New Jersey, Division of Infectious Diseases, Cooper University Hospital, Robert Wood Johnson Medical School, NJ, USA. delaTorre-pola@cooperhealth.edu |
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Abstract: | Anidulafungin, a new echinocandin, has recently been approved for the treatment of esophageal candidiasis, candidemia and other forms of invasive candidiasis, such as peritonitis and intra-abdominal abscesses in non-neutropenic patients. It is fungicidal against Candida spp. including those that are azole- and polyene-resistant and fungistatic against Aspergillus spp. Owing to its poor oral bioavailability it can only be administered intravenously. Its pharmacokinetics allow for once-daily dosing and a steady state concentration is easily achieved on day 2 following a loading dose of double the maintenance dose on day 1. It does not need adjustment for hepatic or renal insufficiency; there are no known drug interactions and it has a favorable tolerability profile. Its mechanism of action, which differs from other classes of antifungals, should prevent cross-resistance with azoles and polyenes. |
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