Four new triterpenoids from the leaves of Psidium guajava |
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Authors: | Shao Meng Wang Ying Huang Xiao-Jun Fan Chun-Lin Zhang Qing-Wen Zhang Xiao-Qi Ye Wen-Cai |
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Affiliation: | Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. |
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Abstract: | Four new triterpenoids, psiguanins A-D (1-4), along with 13 known ones (5-17), were isolated from the leaves of Psidium guajava. The structures of new compounds were determined as 2α,3β-dihydroxy-taraxer-20-en-28-oic acid (1), 2α,3β,12α,13β-tetrahydroxy-urs-28-oic acid (2), 2α,3β,12β,13β-tetrahydroxy-urs-28-oic acid (3), and 2α,3β,12β,13α-tetrahydroxy-urs-28-oic acid (4), respectively, on the basis of comprehensive spectroscopic methods and molecular modeling calculation. Among them, compound 4 was characterized as an unusual ursane-type triterpenoid with cis-fused C/D ring system. |
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