| 肝硬化大鼠肠源性内毒素血症的程度及肝组织中内毒素的分布 |
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| 引用本文： | 李夏青,韩德五,陈贤明.肝硬化大鼠肠源性内毒素血症的程度及肝组织中内毒素的分布[J].山西医科大学学报,2000,31(3):195-196. |
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| 作者姓名： | 李夏青 韩德五 陈贤明 |
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| 作者单位： | 山西医科大学病理生理学教研室,太原,030001 |
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| 摘 要： | 目的 观察ＣＣｌ４所致中晚期硬化大鼠肠源性内毒素血症的程度及肝组织内毒症的分布。材料与方法 采用鲎三肽基质法测定腹主动脉及门静脉血浆内毒素含量；同时，采用免疫组化方法对肝硬化组织内毒素的分布进行观察。结果 ＣＣｌ４所致肝硬化动物血浆内毒素含量明显高于正常，尤以动脉内毒素含量增加而显著；同时，大部分肝脏组织呈内毒素染色阳性，内毒性主要分布于变性之肝细胞浆内，呈中度阳性染色。结论 ＣＣｌ４所致肝硬化伴
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| 关 键 词： | 内毒素 肝硬化 肠源性内毒素血症 |
| 文章编号： | 1007-6611(2000)03—0195-02 |
| 修稿时间： | 1999-11-11 |
Severity of gut - originaled endotoxemia and endotoxin dlstribution in the cirrhotic hepatic lissue |
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| Li Xiaqing,Han Dewu,Chen Xianming.Severity of gut - originaled endotoxemia and endotoxin dlstribution in the cirrhotic hepatic lissue[J].Journal of Shanxi Medical University,2000,31(3):195-196. |
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| Authors: | Li Xiaqing Han Dewu Chen Xianming |
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| Institution: | Li Xiaqing ,Han Dewu ,Chen
Xianming ;
(Dept. Of Pathophysiotogy, Shanri Medical University, Taiyuan 030001) |
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| Abstract: | Objective Gut-originated endotoxemia and distribution of endotoxin in hepatic tissue of cirrhotic rats induced by CCl 4 were investigated. Methods The Distribution of endotoxin in cirrhotic hapatic tissues was studied by the immunohistochemistry,meantime, the severity of gut-originated endotoxemia was evaluated by biochemical methods of limulus amebocyte lysate (LAL). Results There was a moderate positive staining in the cytoplasm of hepatocytes with fatty and bydrolytic degeneration in cirrhotic rats,obviously differing from normal controls. In addition,there was an increased level of endotoxemia in the aorta and portal vein. Conclusion Gut-originated endotoxemia and endotoxin deposition in hepatocytes happen to the cirrhotic rats induced by CCl 4. However, the mechanism of endotoxin into the cytoplasm of hepatocytes in cirrhotic rats is not clarified yet. |
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| Keywords: | endotoxins liver cirrhosis gut-originated endotoxemia |
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