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| 丹参滴注液中丹参素钠在 Beagle 犬体内的药代动力学研究 | |
| 引用本文： | 周玲,张军,谢丽艳,徐洁,稽晶,程建明,居文政,刘子修,刘史佳,谈恒山.丹参滴注液中丹参素钠在 Beagle 犬体内的药代动力学研究[J].中国中药杂志,2012,37(3):373-376. |
| 作者姓名： | 周玲 张军 谢丽艳 徐洁 稽晶 程建明 居文政 刘子修 刘史佳 谈恒山 |
| 作者单位： | 1. 南京中医药大学药学院,江苏南京,210041 2. 南京中医药大学附属医院临床药理科,江苏南京,210046 3. 南京军区总医院,江苏南京,210002 |
| 基金项目： | 江苏省高校优势学科建议工程项目;江苏省中医药领军人才项目(LJ200906) |
| 摘 要： | 目的:探讨丹参滴注液中丹参素钠在Beagle犬体内的药代动力学。方法:健康Beagle犬禁食12 h后,静脉滴注丹参滴注液10 mL.kg-1,血浆样品用乙酸乙酯提取,采用HPLC测定不同时间血药浓度。结果:丹参素钠在0.225～18.000mg.L-1线性关系良好,最低检测限为0.113 mg.L-1,Beagle犬静脉滴注丹参滴注液后的药代动力学参数:tmax为30 min,Cmax为(9.574 2±2.371 5)mg.L-1,t1/2为(19.23±2.97)min,CL为(0.012 7±0.003 0)L.min-1.kg-1,AUC0-tn为(474.954±95.483)mg.min.L-1,AUC0-∞为(482.494±95.353)mg.min.L-1。结论:所建立血药浓度检测方法简便、稳定、可靠,丹参素钠在Beagle犬体内呈单室模型。 |
| 关 键 词： | 丹参滴注液 HPLC 丹参素钠 药代动力学 |
| 收稿时间： | 2011/4/26 0:00:00 |
Study on pharmacokinetics of danshensu sodium in danshen dripping solution in Beagles |
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| ZHOU Ling,ZHANG Jun,XIE Liyan,XU Jie,JI Jing,CHENG Jianming,JU Wenzheng,LIU Zixiu,LIU Shijia and TAN Hengshan.Study on pharmacokinetics of danshensu sodium in danshen dripping solution in Beagles[J].China Journal of Chinese Materia Medica,2012,37(3):373-376. | |
| Authors: | ZHOU Ling ZHANG Jun XIE Liyan XU Jie JI Jing CHENG Jianming JU Wenzheng LIU Zixiu LIU Shijia and TAN Hengshan |
| Institution: | Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China;Department of Clinical Pharmacology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China;Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China;Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China;Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China;Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China;Department of Clinical Pharmacology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China;Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China;Department of Clinical Pharmacology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China;General Hospital of Armed Forces of Nanjing,Nanjing 210002, China |
| Abstract: | Objective:To detect pharmacokinetics of Danshensu Sodium in Danshen dripping solution in Beagles.Method: Danshen dripping solution was dripped intravenously into healthy Beagles at a dose of 10 mL·kg-1.Their plasma samples were extracted with acetic ether,the blood concentrations were determined by HPLC method.Result: Danshensu Sodium showed a good linear relationship within the range of 0.225-18.000 mg·L-1,with the lowest detectable limit of 0.113 mg·L-1.Its pharmacokinetic parameters were as follows: tmax was 30 min,Cmax was(9.574 2±2.371 5) mg·L-1,t1/2 was(19.23±2.97) min,CL was(0.012 7±0.003 0) L·min-1·kg-1,AUC0-tn was(474.954±95.483) mg·min·L-1 and AUC0-∞ was(482.494±95.353) mg·min·L-1.Conclusion: The accurate,stable and reliable blood concentration method shows a one-compartment mode of Danshensu Sodium in Beagles. |
| Keywords: | Danshen dripping solution HPLC Danshensu sodium pharmacokinetics |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ | |