| 三氧化二砷注射液治疗急性早幼粒细胞白血病临床观察 |
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| 引用本文： | 朱熙君,张华满,李梅君.三氧化二砷注射液治疗急性早幼粒细胞白血病临床观察[J].中国伤残医学,2010,18(3). |
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| 作者姓名： | 朱熙君 张华满 李梅君 |
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| 作者单位： | 1. 宣城市人民医院血液科,安徽,宣城,242000
2. 辽宁医学院附属第一医院血液科 |
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| 摘 要： | 目的:观察三氧化二砷(ATO)注射液治疗急性早幼粒细胞白血病(APL)的疗效,以及外周血白细胞和骨髓象的动态改变与临床意义。方法:对27例初诊和2例DA方案治疗复发急性早幼粒细胞白血病给予ATO注射液10mg/d静脉滴注诱导治疗,治疗过程中每2周进行骨髓检查,对白细胞>50×109/L的病人加用小剂量羟基脲化疗。统计数据以SPSS11.5系统软件进行分析。结果:29例病人经ATO诱导分化治疗26例获CR,CR率为89.7%;CR中18例出现白细胞增高,达高峰平均时间为9.2±2.4天,高峰持续时间平均为10.3±4.6天,在整个治疗过程中骨髓未出现增生受抑制的情况,骨髓异常早幼粒细胞计数显著下降(p<0.01),同时呈转化趋势,逐渐向中、晚幼粒细胞转化;并且骨髓中早幼粒细胞的下降与早幼粒细胞以下阶段细胞的上升呈明显相关性(p<0.05)。结论:常规剂量浓度ATO治疗APL诱导治疗缓解率高,副作用轻。
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| 关 键 词： | 三氧化二砷 急性早幼粒细胞白血病 骨髓象 白细胞 |
Clinical Research of Arsenic Trioxide Solution Therapy in Acute Promyelocytic Leukemia |
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| ZHU XU-jun,ZHANG Hua-man,LI Mei-jun.Clinical Research of Arsenic Trioxide Solution Therapy in Acute Promyelocytic Leukemia[J].Chinese JOurnal of Trauma and Disability Medicine,2010,18(3). |
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| Authors: | ZHU XU-jun ZHANG Hua-man LI Mei-jun |
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| Institution: | ZHU XU-jun,ZHANG Hua-man,LI Mei-jun(Department of hematology,Xuanchen people's hospital,Xuancheng,Anhui242000) |
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| Abstract: | Objective:To evaluate the effectiveness of intranvenous arsenic trioxide(ATO)in the treatment of acute promyelocytic leukemia(APL)and the dynamic changes of peripheral white blood cells(WBC)and bone marrow myelocytes during treatment.Methods:Twenty-seven patients with newly diagnosed APL and two returning patients were treated with DA were enrolled.10ml of 0.1% ATO solution was administered intravenously daily.Bone marrow smear was performed two weeks.Peripheral blood count were also measured during the cou... |
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| Keywords: | Arsenic trioxide Acute promyelocytic leukemia Bone marrow smear White blood cells |
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