大肠癌患者血清可溶性E-选择素和细胞间黏附分子-1检测

目的:探讨大肠癌患者血清可溶性E-选择素(sE-selectin)、细胞间黏附分子-1(sICAM-1)检测的意义.方法:采用ELISA检测40例大肠癌患者术前、术后15 d、术后30 d及20例对照(健康体检者)血清sE-selectin、sICAM-1水平.结果:大肠癌患者术前血清sE-selectin、sICAM-1水平高于对照组(P＜0.05);术后15 d下降,但仍高于对照组(P＜0.05);术后30 d降至对照组水平(P＞0.05).大肠癌患者血清sE-selectin、sICAM-1水平与淋巴结转移和临床分期有关(P＜0.05),与年龄、性别、肿瘤大小及组织学分级无关(P＞0.05).结论:sE-selectin、sICAM-1可能参与了大肠癌侵袭转移过程,是反映大肠癌发生、发展及预后的重要指标.

Detection of serum soluble E-selectin and intercellar adhesion molecule-1 in patients with colorectal carcinoma

Aim:To investigate the significance of serum soluble E-selectin(sE-selectin)and intercellar adhesion molecule-1(sICAM-1)detection in patients with colorectal carcinoma.Methods:The serum sE-selectin and sICAM-1 levels in 20 healthy people and 40 patients with colorectal carcinoma pre-operation and 15 days,30 days after operation,were tested by ELISA technique.Results:The serum sE-selectin and sICAM-1 levels in patients with colorectal carcinoma were significantly higher than that of normal control before operation(P<0.05),began to decrease 15 days after operation,and decreased to the levels of the normal control 30 days after operation(P>0.05).The serum sE-selectin and sICAM-1 levels of patients with colorectal carcinoma were correlated with the metastases of lymph node and the stage(P<0.05),while had no relation to sex,age,tumor size and histological grades(P>0.05).Conclusion:sE-selectin and sICAM-1 may be involved in the colorectal carcinoma invasion and metastases,and may be a index reflecting pathogenesis,development and prognosis of colorectal carcinoma.