Successful treatment of chronic recurrent multifocal osteomyelitis with tumor necrosis factor-alpha blockage |
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Authors: | Deutschmann Andrea Mache Christoph J Bodo Koppany Zebedin Doris Ring Ekkehard |
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Institution: | Department of Pediatrics, Medical University of Graz, Graz, Austria. andrea.deutschmann@meduni-graz.at |
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Abstract: | We describe the case of an 18-year-old girl with chronic recurrent multifocal osteomyelitis (CRMO) over a period of 10 years. She had suffered predominantly from very painful recurrent swelling of her cheeks. Various therapeutic regimens including nonsteroidal antiinflammatory drugs and steroids had shown only a partial or temporary response. Because tumor necrosis factor-alpha-blocking agents have been successfully applied in Crohn's-associated CRMO and the related SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome, tumor necrosis factor-alpha-blocking therapy with infliximab was initiated. Thereafter, apart from 1 mild episode, no additional recurrences were observed during 21 months of follow-up. Infliximab was well tolerated, and steroids were tapered off. Our observation indicates that infliximab may be an effective therapeutic option in CRMO. |
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