赖诺普利联合螺内酯治疗慢性充血性心力衰竭的疗效观察

目的:观察赖诺普利联合螺内酯治疗慢性充血性心力衰竭(CHF)的临床疗效。方法:将120例慢性CHF患者随机均分为对照组和治疗组。对照组进行常规强心、利尿治疗;治疗组在对照组基础上加用赖诺普利10mg.d-1、螺内酯40mg.d-1。治疗后观察2组临床疗效、心脏功能变化及不良反应。结果:治疗组总有效率为83.33%,对照组总有效率为50.00%,2组比较差异有统计学意义(P<0.05)。治疗后2组收缩压、舒张压及心率比较,治疗组显著优于对照组(P<0.05)。治疗组未见明显高血脂、肾功能恶化等不良反应发生。结论:赖诺普利与螺内酯联合应用能明显改善心功能,疗效较好。

Efficacy Observation of Lisinopril and Spironolactone in the Treatment of Chronic Congestive Heart Failure

OBJECTIVE:To observe the curative effect of lisinopril and spironolactone on chronic congestive heart failure(CHF).METHODS:120 cases of CHF were randomly divided into the control group(60 cases) and treatment group(60 cases).Control group was given conventional treatment of cardiac stimulation and diuresis.Treatment group was additionally given lisinopril(10 mg·d-1) and spironolactone(40 mg·d-1) on the basis of conventional treatment.The changes of clinical efficacy and heart function of 2 groups were observed.RESULTS:In treatment group,the total effective rate was 83.33%;In control group,the total effective rate was 50.00%.There was statistical significance(P<0.05).No obvious high blood lipid,kidney degradation and other adverse drug reactions were observed in treatment group.The SBP,DBP,heart rate of 2 groups after treatment compared,the treatment group were better(P<0.05).CONCLUSIONS:Lisinopril combined with spironolactone can significantly improve heart function with low ADR and good effects.