Feedback control of transmitter release at the neuromuscular junction |
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| Authors: | W C Bowman I G Marshall A J Gibb A J Harborne |
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| Affiliation: | 1. The authors'' research described here was carried out in the Department of Physiology and Pharmacology of the University of Strathclyde, Glasgow G1 1XW, UK;2. Alasdair Gibb is currently working in the Department of Pharmacology of University College, London, UK;1. Section of Pharmacology, Department of Pharmacy and Drug Sciences, University of Bari Aldo Moro, 70125, Bari, Italy;2. Section of Medicinal Chemistry, Department of Pharmacy and Drug Sciences, University of Bari Aldo Moro, 70125, Bari, Italy;3. Section of Pharmacology, Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, 70126 Bari, Italy;1. Department of Emergency Medicine, Alpert Medical School of Brown University, Providence, Rhode Island;2. Department of Pharmacy, Rhode Island Hospital, Providence, Rhode Island;1. Department of Pediatrics, Texas Tech University Health Sciences Center, 1400 Wallace Boulevard, Amarillo, TX 79106, USA;2. Department of Obstetrics and Gynecology, Texas Tech University Health Sciences Center, 1400 Coulter Street, Amarillo, TX 79106, USA |
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| Abstract: | There is evidence that acetylcholine, in addition to acting on postjunctional receptors to fulfil its transmitter role, also acts on prejunctional nicotinic autoreceptors to facilitate mobilization of the transmitter. Hence, the availability of the transmitter at the sites of release keeps pace with the demand for it. Bill Bowman and colleagues demonstrate that block of the prejunctional receptors by tubocurarine and related drugs leads to a reduction in acetylcholine output and consequently to the characteristic fade of tetanic tension and rundown in trains of endplate currents. |
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