| Effect of Early Hemofiltration on Pro- and Anti-inflammatory Responses and Multiple Organ Failure in Severe Acute Pancreatitis |
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| 引用本文： | 杨智勇,王春友,陶京,熊炯炘,万赤丹,周锋. Effect of Early Hemofiltration on Pro- and Anti-inflammatory Responses and Multiple Organ Failure in Severe Acute Pancreatitis[J]. 华中科技大学学报(医学英德文版), 2004, 24(5): 456-459. DOI: 10.1007/BF02831107 |
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| 作者姓名： | 杨智勇 王春友 陶京 熊炯炘 万赤丹 周锋 |
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| 作者单位： | Pancreatic Surgery，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，China，Pancreatic Surgery，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，China，Pancreatic Surgery，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，China，Pancreatic Surgery，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，China，Pancreatic Surgery，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，China，Pancreatic Surgery，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，China |
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| 摘 要： | Severeacute pancreatitis (SAP )progressesrapidlywithacomplicatedoutcomeandhighmortali ty .Themultipleorgandysfunctionsyndrome(MODS)inducedbytheoverreleaseofcytokineswhichisthemaincauseofpatients’deathsintheear lystage[1] .Hemofiltration (HF)isoneoftheblo…
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| 关 键 词： | TNF-α SAP IL-10 IL-1β HF PaO2 ALT HR |
| 收稿时间： | 2003-09-20 |
Effect of early hemofiltration on pro- and anti-inflammatory responses and multiple organ failure in severe acute pancreatitis |
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| Yang Zhiyong,Wang Chunyou,Tao Jing,Xiong Jiongxin,Wan Chidan,Zhou Feng. Effect of early hemofiltration on pro- and anti-inflammatory responses and multiple organ failure in severe acute pancreatitis[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2004, 24(5): 456-459. DOI: 10.1007/BF02831107 |
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| Authors: | Yang Zhiyong Wang Chunyou Tao Jing Xiong Jiongxin Wan Chidan Zhou Feng |
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| Affiliation: | Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China |
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| Abstract: | Summary The effects of early hemofiltration on the serum levels of cytokines, pro-and anti-inflammatory balance and organ function in pigs with severe acute pancreatits (SAP) were studied. SAP pig model was induced by retrograde injection of artificial bile into the pancreatic duct. The pigs were randomly divided into SAP hemofiltration treatment group (HF group,n=8) and SAP nonhemofiltration treatment group (NHF group,n=8). In the HF group, the animals were subjected to high-volume and zero-balance hemofiltration therapy. The results showed that as compared with NHF group, MAP, CVP and PaO2/FiO2 were significantly increased (P<0.01), while HR, urinary protein content, serum ALT level, pulmonary coefficient and lung wet/dry ratio obviously decreased (P<0.05) in HF group. Under a light microscope, the pulmonary histologic scoring was lower that in HF group (P<0.01) and the lesions of renal and liver tissues were milder. However, there was no significant difference in the pancreatic histologic scoring between the two groups. Six h after establishment of the model, the serum levels of TNF-α, IL-1β were lower, while the IL-10/TNF-α ratio was higher in HF group (allP<0.05). It was suggested that early hemofiltration could effectively remove the serum cytokines TNF-α and IL-1β in SAP pigs, elevate the ratio of IL-10/TNF-α, improve hemodynamics and alleviate the lesions of lung, kidney and liver tissues. YANG Zhiyong, male, born in 1977, Doctoral Candidate |
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| Keywords: | severe acute pancreatitis hemofiltration multiple organ failure cytokines |
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