| 复方黄酮胶囊的急性毒性作用研究 |
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| 引用本文： | 潘洪平,危华玲,陈英,钟正贤,陈学芬,李燕婧.复方黄酮胶囊的急性毒性作用研究[J].时珍国医国药,2007,18(10):2378-2378. |
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| 作者姓名： | 潘洪平 危华玲 陈英 钟正贤 陈学芬 李燕婧 |
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| 作者单位： | 1. 广西壮族自治区人民医院,广西,南宁,530021
2. 广西壮族自治区中医药研究所,广西,南宁,530022 |
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| 基金项目： | 广西壮族自治区卫生厅计划课题（No.Z2003081） |
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| 摘 要： | 目的观察复方黄酮胶囊的急性毒性反应。方法复方黄酮胶囊以最大浓度及最大给药体积的药液灌胃给药,3次/d。连续观察7 d,记录小鼠毒副反应情况。结果观察7 d后,全部动物健存,小鼠体重平均增长为25.08%,未见任何毒性反应。计算其最大给药量为783.38 mg槲皮素/kg体重,相当于成人日用量的39.33倍。结论提示复方黄酮胶囊毒性较小。
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| 关 键 词： | 复方黄酮胶囊 小鼠 急性毒性实验 |
| 文章编号： | 1008-0805（2007）10-2378-01 |
| 收稿时间： | 2007-02-02 |
| 修稿时间： | 2007-04-29 |
Experimental Study on the Acute Toxicity of Compound Flavone Capsules in Mice |
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| PAN Hong-ping,WEI Hua-ling,CHEN Ying,ZHONG Zheng-xian,CHEN Xue-fen,LI Yan-jing.Experimental Study on the Acute Toxicity of Compound Flavone Capsules in Mice[J].Lishizhen Medicine and Materia Medica Research,2007,18(10):2378-2378. |
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| Authors: | PAN Hong-ping WEI Hua-ling CHEN Ying ZHONG Zheng-xian CHEN Xue-fen LI Yan-jing |
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| Abstract: | Objective To study the toxic reaction on Compound Flavone Capsules in mice.Methods The maximum administration dosage of compound Flavone capsules were determined by ig administration in mice,three times a day.Its acute toxic reactions were observed for consecutive 7 days.Results All mice survived,and no toxic reaction was shown in the observed period.The average rate of its increasing weight was 25.08 percent.The maximum administration dosage was 783.38 mg of quercetin given to mice per kilogram,equivalent to men's daily administration dosage by 39.33 times.Conclusion Compound Flavone Capsules is safety for oral administration. |
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| Keywords: | Compound Flavone Capsules Mice Acute toxicity |
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