| 奥曲肽对晚期消化道肿瘤患者血清胰岛素样生长因子-I水平的影响 |
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| 引用本文： | 薛绮萍,杨美南. 奥曲肽对晚期消化道肿瘤患者血清胰岛素样生长因子-I水平的影响[J]. 胃肠病学, 2005, 0(6) |
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| 作者姓名： | 薛绮萍 杨美南 |
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| 作者单位： | 南京医科大学第一附属医院老年消化科 210029 |
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| 摘 要： | 背景:奥曲肽是一种体外合成的生长抑素类似物,其对肿瘤细胞的抑制作用越来越受到人们的关注。新生血管形成对肿瘤的生长和转移起重要作用。许多抗新生血管形成的治疗已经引入临床试验,生长抑素类似物可用作抗新生血管形成的治疗。目的:评价奧曲肽治疗晚期消化道肿瘤的临床受益反应(CBR)及其对患者血清胰岛素样生长因子(IGF)-Ⅰ水平的影响,探讨奥曲肽的抗肿瘤作用机制。方法:予28例晚期消化道肿瘤患者奥曲肽0.2mg。每12h皮下注射1次,直至病情进展或不能耐受治疗为止,综合评估CBR;采用双抗体夹心酶联免疫吸附测定(ELISA)检测治疗前和治疗1个月后的血清IGF-Ⅰ水平。结果:奥曲肽治疗的总体CBR率为60.7％(17/28);治疗1个月后,患者血清IGF-Ⅰ水平(54.8ng/L±27.4ng/L)较治疗前(183.1ng/L±56.6ng/L)显著下降(P<0.01),其中19例(67.9％)患者为明显下降。结论:奥曲肽能显著降低晚期消化道肿瘤患者血清IGF-Ⅰ水平,抑制肿瘤生长,使患者获得较高的CBR率。
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| 关 键 词： | 奥曲肽 消化系统肿瘤 胰岛素样生长因子Ⅰ 临床受益反应 酶联免疫吸附测定 |
Effect of Octreotide on Serum Insulin-like Growth Factor-I Level in Patients with Advanced Gastrointestinal Tumors |
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| XUE Qiping,YANG Meinan Deparment of Geriatric Gastroenterology,The First Affiliated Hospital of Nanjing Medical University,Nanjing. Effect of Octreotide on Serum Insulin-like Growth Factor-I Level in Patients with Advanced Gastrointestinal Tumors[J]. Chinese Journal of Gastroenterology, 2005, 0(6) |
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| Authors: | XUE Qiping YANG Meinan Deparment of Geriatric Gastroenterology The First Affiliated Hospital of Nanjing Medical University Nanjing |
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| Affiliation: | XUE Qiping,YANG Meinan Deparment of Geriatric Gastroenterology,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029 |
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| Abstract: | |
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| Keywords: | Octreotide Digestive System Neoplasms Insulin-Like Growth Factor I: Clinical Benefit Response Enzyme--Linked Immunosorbent Assay |
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