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Longitudinal Analysis of Multiple Neurotransmitter Metabolites in Cerebrospinal Fluid in Early Parkinson's Disease |
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| Authors: | Thomas Kremer PhD Kirsten I. Taylor PhD Juliane Siebourg-Polster PhD Thomas Gerken PhD Andreas Staempfli PhD Christian Czech PhD Juergen Dukart PhD Douglas Galasko MD Tatiana Foroud PhD Lana M. Chahine MD Christopher S. Coffey PhD Tanya Simuni MD Daniel Weintraub MD John Seibyl MD Kathleen L. Poston MD Arthur W. Toga PhD Caroline M. Tanner MD PhD Kenneth Marek MD Samantha J. Hutten PhD Sebastian Dziadek PhD Claudia Trenkwalder MD Gennaro Pagano MD Brit Mollenhauer MD |
| Affiliation: | 1. Roche Pharmaceutical Research and Early Development, NRD Neuroscience and Rare Diseases, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Basel, Switzerland;2. Roche Pharmaceutical Research and Early Development, NRD Neuroscience and Rare Diseases, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Basel, Switzerland Faculty of Psychology, University of Basel, Basel, Switzerland;3. Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Basel, Switzerland;4. Metanomics Health GmbH, Berlin, Germany;5. Roche Pharmaceutical Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Basel, Switzerland;6. Roche Pharmaceutical Research and Early Development, NRD Neuroscience and Rare Diseases, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Basel, Switzerland Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Julich, Germany Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany;7. Department of Neurosciences, University of California, San Diego, San Diego, California, USA;8. Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA;9. Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA;10. Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, USA;11. Parkinson's Disease and Movement Disorders Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA;12. Department of Neurology Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA;13. Institute for Neurodegenerative Disorders, New Haven, Connecticut, USA;14. Department of Neurology & Neurological Sciences, School of Medicine, Stanford University, Stanford, California, USA;15. Laboratory of Neuro Imaging, University of Southern California (USC) Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA;16. Department of Neurology, University of California, San Francisco, San Francisco, California, USA Parkinson's Disease Research Education and Clinical Center, San Francisco Veterans Affairs Health Care System, San Diego, California, USA;17. Institute for Neurodegenerative Disorders, New Haven, Connecticut, USA The Michael J. Fox Foundation for Parkinson's Research, New York, New York, USA;18. The Michael J. Fox Foundation for Parkinson's Research, New York, New York, USA;19. Department of Neurosurgery, University Medical Center Göttingen, Göttingen, Germany Paracelsus-Elena-Klinik, Kassel, Germany;20. Paracelsus-Elena-Klinik, Kassel, Germany Department of Neurology, University Medical Center Göttingen, Göttingen, Germany |
| Abstract: | |
| Keywords: | monoamine metabolites catecholamine neurotransmitter biomarker Parkinson's disease CSF homovanillic acid |