Effects of sildenafil on inflammatory injury of the lung in sodium taurocholate-induced severe acute pancreatitis rats期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Effects of sildenafil on inflammatory injury of the lung in sodium taurocholate-induced severe acute pancreatitis rats

Abstract:	BackgroundInflammatory response and acute lung injury (ALI) occur in sodium taurocholate-induced severe acute pancreatitis (SAP). Because sildenafil has anti-inflammatory, anti-oxidant and immune-modulating effects, we investigated its effect on inflammatory and lung injury in sodium taurocholate-induced SAP-associated ALI rat lung.MethodsSodium taurocholate-induced SAP rats received sildenafil (100 mg/kg) or not and were compared to age-matched normal control animals. We evaluated inflammatory response by detecting the expression of inflammatory factors including IL-1β, IL-6 and TNF-α, and detected the level of lung injury through histopathological evaluation. Moreover, we also tested the protein expression of PCNA, P21, Bcl-2 and Bax in the lung.ResultsSildenafil administration rats had a low level of lung injury and inflammation. In addition, sildenafil significantly increased the expression of proliferation-related markers and decreased the expression of apoptosis-related markers in lung tissue.ConclusionsSildenafil administration may attenuate inflammation and lung injury by promoting proliferation and suppressing apoptosis in SAP rats.

Keywords:	Sildenafil SAP Lung injury Inflammation Nrf2 NF-κb SAP"} {"#name":"keyword" "$":{"id":"k0040"} "$$":[{"#name":"text" "_":"severe acute pancreatitis ALI"} {"#name":"keyword" "$":{"id":"k0050"} "$$":[{"#name":"text" "_":"acute lung injury Nrf2"} {"#name":"keyword" "$":{"id":"k0060"} "$$":[{"#name":"text" "_":"nuclear erythroid-related factor 2 HO-1"} {"#name":"keyword" "$":{"id":"k0070"} "$$":[{"#name":"text" "_":"heme oxygenase-1 NF-κb"} {"#name":"keyword" "$":{"id":"k0080"} "$$":[{"#name":"text" "_":"nuclear factor-kB IL-1β"} {"#name":"keyword" "$":{"id":"k0090"} "$$":[{"#name":"text" "_":"interleukin-1β IL-6"} {"#name":"keyword" "$":{"id":"k0100"} "$$":[{"#name":"text" "_":"interleukin-6 TNF-α"} {"#name":"keyword" "$":{"id":"k0110"} "$$":[{"#name":"text" "_":"tumor necrosis factor-alpha MPO"} {"#name":"keyword" "$":{"id":"k0120"} "$$":[{"#name":"text" "_":"Myeloperoxidase MCP-1"} {"#name":"keyword" "$":{"id":"k0130"} "$$":[{"#name":"text" "_":"Monocyte chemoattractant protein-1
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