Endoscopic photodynamic therapy for oesophageal disease |
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Authors: | Hugh Barr FRCS FRCSE Catherine Kendall Florian Bazant-Hegemark Nicholas Stone |
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Affiliation: | aBiophotonics Research Group, Cranfield Postgraduate Medical School, Gloucestershire Royal NHS Foundation Trust, Great Western Road, Gloucester GL1 3NN, UK |
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Abstract: | Photodynamic therapy is a very important technique for the eradication of widespread oesophageal mucosal disease which has the potential to degenerate to cancer. Patients unsuitable or unwilling to undergo radical therapy can be cured using photodynamic therapy. We predominantly treat patients with high-grade dysplasia in Barrett's oesophagus. Lesions that are visible macroscopically are removed using endoscopic mucosal resection. The remaining area is then treated in 5 cm segments at 3 monthly intervals with separate photosensitisation using endoscopic photodynamic therapy. |
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Keywords: | Photodynamic therapy Photofrin Aminolaevulinic acid Barrett's oesophagus |
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