Ezrin在涎腺腺样囊性癌组织中的表达

目的:探讨Ezrin在涎腺腺样囊性癌组织中的表达及意义。方法:用免疫组织化学SP法检测Ezrin在涎腺腺样囊性癌组织和正常涎腺组织中的表达,分析其在涎腺腺样囊性癌组织中的表达与肿瘤的侵袭性、复发、转移和预后的关系。结果:Ezrin在涎腺腺样囊性癌和正常涎腺组织中的阳性率表达分别为44.68%和9.09%,P<0.05;在癌细胞中主要为胞质内表达,染色深,而在正常涎腺组织则主要为细胞膜表达,染色浅或阴性。Ezrin的表达强度与有无神经受侵、有无发生局部复发及远处转移相关,P<0.05。Ezrin表达阳性组和阴性组的5年累积生存率分别为66.70%和100.00%,10年累及生存率分别为27.83%和95.00%,阳性组较阴性组预后差,P<0.05。结论:Ezrin的表达强度与涎腺腺样囊性癌的发生、侵袭性、复发和转移性有关,且Ezrin阳性表达预示患者预后不良。

Ezrin expression in adenoid cystic carcinoma of salivary gland

OBJECTIVE:To study the expression and significance of Ezrin in adenoid cystic carcinoma of salivary gland. METHODS: The expression of Ezrin was detected by the immunohistochemical method in adenoid cystic carcinoma of salivary gland and normal salivary gland tissues, and the correlations among the expression of Ezrin in adenoid cystic carcinoma of salivary gland and invasion, occurrence, metastasis and prognosis were analyzed. RESULTS: The over expression rates of Ezrin in adenoid cystic carcinoma of salivary gland and normal salivary gland tissues were 44.68% and 9.09%, respectively, P<0.05; in the adenoid cystic carcinoma tissue, strong Ezrin immunostaining was detected mainly in the cytoplasma, whereas in the normal salivary gland tissue, Ezrin immunostaining was observed principally in the membrane and varied in intensity from weak to negative. The intensity of Ezrin expression was associated with the presence or absence of nerve invasion, locoregional recurrence and distant metastasis, P<0.05. The 5-year cumulative survival rates in positive Ezrin expression group and negative Ezrin expression group were 66.70% and 100.00%, respectively; 10-year cumulative survival rates were 27.83% and 95.00%, respectively, and the positive Ezrin expression group had worse prognosis than the negative one, P<0.05. CONCLUSION: The intensity of Ezrin expression is correlated with the genesis and ability of invasion, occurrence and metastasis of adenoid cystic carcinoma of salivary gland, and its positive expression indicates poor prognosis.