| 基因重组乳链球菌防龋疫苗口服免疫孕兔的实验研究 |
| |
| 引用本文： | 刘建国,樊明文,边专,凌均启,汪喻忠,陈罕.基因重组乳链球菌防龋疫苗口服免疫孕兔的实验研究[J].口腔医学研究,1996(4). |
| |
| 作者姓名： | 刘建国 樊明文 边专 凌均启 汪喻忠 陈罕 |
| |
| 作者单位： | 武汉市湖北医科大学口腔医学院，遵义医学院口腔系 |
| |
| 摘 要： | 作者研究了重组链球菌ＨＬ１０７口服免疫孕兔的效果。使用酶联免疫吸附法测定口服免疫前后血清、唾液和乳汁中抗表面蛋白抗原ＩｇＧ、ＩｇＡ抗体水平。结果表明口服免疫孕兔后血清和乳汁中特异性抗表面蛋白抗原的ＩｇＧ水平明显升高，唾液和乳汁中抗表面蛋白抗原的ＩｇＡ水平明显升高，提示重组乳链球菌ＨＬ１０７具有变形链球菌表面蛋白抗原的免疫原性，能够激发针对表面蛋白质抗原的系统免疫和局部粘膜的免疫反应。
|
| 关 键 词： | 变形链球菌，乳链球菌，免疫，疫苗 |
Oral immunization with recombinant S. lactis carrying the S. mutans surface protein antigen gene in pregnant rabbits |
| |
| Liu Jianguo, Fan Mingwen, Bian Zhuan,et al..Oral immunization with recombinant S. lactis carrying the S. mutans surface protein antigen gene in pregnant rabbits[J].Journal of Oral Science Research,1996(4). |
| |
| Authors: | Liu Jianguo Fan Mingwen Bian Zhuan |
| |
| Abstract: | The authors studied the effect of oral immunization in pregnant rabbits with recombinant S. lactis HL107.The level of anti-PAc IgG, IgA in milk, serum and saliva was measured with ELISA before and after oral immunization. The result indicated that specific anti-PAc IgG in serum and milk and specific anti-PAc IgA in saliva and milk were induced to high level after oral immunization. It suggests that the recombinant S. lactis HL107 possesses immunogenicity of 5 mutans surface protein and be able to develope specific systematic and local mucosa immune response againat PAc. |
| |
| Keywords: | S mutans S lactis Immune Vaccine |
| 本文献已被 CNKI 等数据库收录！ |
