糖类对先导化合物的化学修饰及其在药学中的应用

概述了国内外有关糖类对先导化合物化学修饰的研究，从单糖，二糖和寡糖，多糖三个层面，分别对糖及其省生物与先导化合物的键合方式，经过结构修饰的先导化合物的生物活性变化作了综述，结果表明，修饰过的先导化合物能有效地降低毒副作用，增强药效，所以，利用糖类对先导化合物进行化学饰是很有前途的研究领域。

Chemical modification of lead compounds by monasacchrides and their derivatives

As a summary of the research progress of chemical modification of lead compounds by saccharides and their derivatives, this article studies the linkage style of saccharides with lead compounds and bioactivity changes of the modified lead compounds. The result shows that the modified lead compounds can decrease the toxicity and side effect efficiently, and enhance the pharmacal effect. Therefore, it is a promising research project to modify lead compounds by saccharides.