| 硫酸二乙酯作乙基化剂制备-7氯-1-乙基-6-氟1,4-二氢-4-氧喹啉-3-羧酸的工艺改进 |
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| 引用本文： | 张荣根,刘睿斌,谌虹,周莉莉.硫酸二乙酯作乙基化剂制备-7氯-1-乙基-6-氟1,4-二氢-4-氧喹啉-3-羧酸的工艺改进[J].华西药学杂志,1991(2). |
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| 作者姓名： | 张荣根 刘睿斌 谌虹 周莉莉 |
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| 作者单位： | 西南制药二厂，西南制药二厂，西南制药二厂，西南制药二厂 重庆 630061，重庆 630061，重庆 630061，重庆 630061 |
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| 摘 要： | 本文采用硫酸二乙酯与7-氯-6-氟-4-羟基喹啉-3-羧酸乙酯反应,然后用氢氧化钠液水解得7-氯-1-乙基-6-氟-1,4-二氢-4-氧喹啉-3-羧酸。其总收率为80％,此法降低了原料成本,简化了工艺,适合工业生产。
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| 关 键 词： | 诺氟沙星 喹诺酮类 7-氯-1-乙基-6-氟-1 4-二氢-4-氧喹啉-3-羧酸 |
IMPROVED SYNTHESIS OF 7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-QUINOLINE-3-CARBOXYLIC ACID WITH DIETHYL SULFATE |
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| Zhang Yonggen Liu Ruibin Zhen Hong Zhou Lili.IMPROVED SYNTHESIS OF 7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-QUINOLINE-3-CARBOXYLIC ACID WITH DIETHYL SULFATE[J].West China Journal of Pharmaceutical Sciences,1991(2). |
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| Authors: | Zhang Yonggen Liu Ruibin Zhen Hong Zhou Lili |
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| Institution: | Second Southwest Pharmaceutical Faxtory Chongqing |
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| Abstract: | 7-Chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid was Preparod by ethylation of the 7-chloro-6-fluoro-4-hydroxyquino-line-3-carboxylic acid ethyl ester with diethyl sulfate and hydrolysis of 7-chloto-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid ethyl ester with aqueous sodium hydroxide yield 80%. |
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| Keywords: | Norfloxacin Quinolines 7-chloro-1-ethyl-6-fluoro-1 4-dihydro-4-oxo-quinoline-3-Carboxylic acid |
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