近红外光谱技术在HIE患儿脑氧饱和度检测的临床应用研究

目的：研究近红外光谱技术在新生儿缺氧缺血性脑病（Hypoxic ischemic encephalopathy,HIE）脑氧饱和度（regional oxygen saturation,rSO2）检测的临床应用价值。方法：收集我院2006年至2009年HIE患儿70例（包括轻度HIE组46例及中、重度HIE组24例）,同时收集产科同期的足月健康儿30例作为对照组,分别在12h、24 h、72 h用近红外光谱检测技术（near infrared spectroscopy,NIRS）测定安静状态下的rSO2,并使用脉搏血氧仪监测SpO2,进行组间比较。结果：NIRS数据显示3组不同时间rSO2组间差异有显著统计学意义（P〈0.05）,在轻型HIE组,各时间的rSO2差异有统计学差异（P〈0.05）;而SpO2监测分析,中、重度HIE组,轻度HIE组与对照组之间差异无统计学意义（p〉0.05）。结论：在新生儿HIE时,NIRS能准确监测rSO2,客观评价脑组织的氧合状态,为评价HIE患儿脑损伤程度提供客观、量化的依据。

Study on the Clinical Application of Near Infrared Spectroscopy in Detecting Regional Oxygen Saturation in Neonatal Hypoxic Ischemic Encephalopathy

Objective： To study the clinical application of near infrared spectroscopy in detecting regional oxygen saturation （ rSO2 ） in neonatal hypoxic ischemic encephalopathy （ HIE ）. Method： Collected 70 cases of neonatal with HIE from 2006 to 2009 in our hospital （ including mild HIE group 46 cases and the moderate and severe HIE group 24 cases） and 30 cases of full - term healthy infants as control group at Obstetrics, the rSO2 was detected using near infrared spectroscopy （ NIRS） at 12h, 24 h, 72 h respectively. While the the SpO2 was detected by using the pulse oximeter for monitoring. Result： NIRS data showed rSO2 of three groups at different time had significant difference between them （ P 〈 0.05 ）. In mild HIE group, rSO2 of each time had statistically significant difference （ P 〈 0.05 ） ; and SpO2 data showed moderate and severe HIE group and mild HIE group and control group were no statistically significant difference between them （ P 〉 0.05 ）. Conclusion： In HIE infants, NIRS can monitor the rSO2 accurately, evaluate brain tissue oxygenation status objectively, provide an objective and quantitative basis.