前列腺素E_1治疗慢性肾脏病基础上急性肾损伤的疗效观察

目的:探讨前列腺素E1治疗在慢性肾脏病基础上急性肾损伤(A/C)的疗效。方法:将78例A/C患者分为两组,治疗组(40例)予常规治疗,并加用前列腺素E1静脉滴注,对照组(38例)予常规治疗。疗程2周,观察治疗前后两组患者肾功能和24h尿蛋白排泄量的变化,比较两组的治疗效果;同时分析A/C发生的危险因素。结果:导致A/C发生的危险因素中,两组均以严重感染、恶性高血压为多见;治疗组于治疗2周后肾功能及尿蛋白排泄量明显改善(P<0.01),而对照组仅肾功能有所改善(P<0.05),治疗组肾功能及尿蛋白排泄量改善程度比对照组明显(P<0.01)。结论:及时诊断和纠正慢性肾脏病基础上急性肾损伤的危险因素,在常规治疗基础上联合应用前列腺素E1治疗可进一步改善患者肾功能,减少尿蛋白,延缓慢性肾脏病的进展。

Effects of Prostaglandin E1 on Patients with Acute Kidney Injury on Chronic Kidney disease

Objective：To investigate the clinical effects of prostaglandinE1（PGE1）on patients with acute kidney injury on chronic kidney disease（A/C）.Methods：78 patients with A/C were divided into two groups ：the patients in the treatment group（n=40）received conventional treatment and PGE1,and the patients in the control group（n=38）only receivesd the conventional treatment.The course of treatment was 2 weeks.Changes of the renal function and 24-hours urine protein excretion were observed before and after therapy,and compared with effectiveness of two groups.Analyed the risk factors of A/C.Results：Among the risk factors of case A/C,the main ones were severe infection and malignant hypertension in both of the groups.After 2 weeks therapy,the renal function and proteinuria were significantly improved in treatment group（P〈0.01）,while the renal function was only improved in the control group（P〈0.05）,The effect in treatment group was superior to the control group（P〈0.01）.Conclusion：It is very important for patients with A/C to recognize and correct the high of acute kidney injury risk factors timely.PGE1 can further improve the renal function in the patients with A/C and decrease proteinuria,delay the progress of chronic kidney disease.