| 肾糖颗粒对糖尿病肾病大鼠疗效的实验研究 |
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| 引用本文： | 傅晓骏,熊荣兵,张婷. 肾糖颗粒对糖尿病肾病大鼠疗效的实验研究[J]. 中国中医急症, 2011, 20(2): 264-266 |
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| 作者姓名： | 傅晓骏 熊荣兵 张婷 |
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| 作者单位： | 浙江中医药大学附属金华中医院,浙江,金华,321017 |
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| 基金项目： | 浙江省金华市科技计划项目 |
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| 摘 要： | 目的通过中药肾糖颗粒对糖尿病大鼠的治疗作用,探讨其临床实验效果。方法采用高脂饲料喂养＋STZ腹腔注射方法制作糖尿病肾病大鼠模型。分为正常对照组、模型对照组、中药治疗组（肾糖颗粒）、西药治疗组（盐酸贝那普利）、中西药治疗组（肾糖颗粒＋盐酸贝那普利）,观察各组大鼠治疗前后一般情况,并测定治疗后空腹血糖,24h尿蛋白定量,尿微量白蛋白,α1-微球蛋白、β2-微球蛋白、尿转铁蛋白、尿视黄醇结合蛋白。结果经肾糖颗粒治疗8周后,大鼠一般状况较模型对照组改善较好,体质量增加。空腹血糖,与模型组比较,各治疗组显著降低;24h尿蛋白定量、尿微量白蛋白、α1-微球蛋白、β2-微球蛋白,各治疗组也分别显著低于模型组;尿转铁蛋白、尿视黄醇结合蛋白,各治疗组均分别显著低于模型组。结论肾糖颗粒对糖尿病肾病大鼠有治疗效果,可以改善其肾功能,延缓糖尿病的肾脏损伤。
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| 关 键 词： | 肾糖颗粒 糖尿病肾病 疗效研究 |
Effect of Renal Sugar Granules on the Diabetic Nephropathy Rats |
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| FU Xiao-jun,XIONG Rong-bing,ZHANG Ting. Effect of Renal Sugar Granules on the Diabetic Nephropathy Rats[J]. Journal of Emergency in Traditional Chinese Medicine, 2011, 20(2): 264-266 |
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| Authors: | FU Xiao-jun XIONG Rong-bing ZHANG Ting |
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| Affiliation: | FU Xiao-jun,XIONG Rong-bing,ZHANG Ting Jinhua City Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University(Jinhua,Zhejiang 321017) |
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| Abstract: | Objective:To observe the efficacy of renal sugar granules on STZ-induced diabetic nephropathy rats.Methods:The model was induced by feeding with high fat diet and STZ produced by intraperitoneal injection in rats.All rats were randomly divided into 5 groups including the normal control group,the model control group,the Chinese medicine group(Renal sugar granule group),the western medicine group(Lotensin group) and the Chinese and Western medicine group(Renal sugar granule and Lotensin group).The general sit... |
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| Keywords: | Renal sugar granules Diabetic nephropathy Efficiency reaserch |
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