扩散和灌注加权成像对兔脑缺血半暗带的量化 |
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引用本文: | 姜传武,刘学军,刘珍友,李文华,隋庆兰,徐文坚,许波. 扩散和灌注加权成像对兔脑缺血半暗带的量化[J]. 中国中西医结合影像学杂志, 2011, 9(1): 4-8. DOI: 10.3969/j.issn.1672-0512.2011.01.002 |
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作者姓名: | 姜传武 刘学军 刘珍友 李文华 隋庆兰 徐文坚 许波 |
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作者单位: | 1. 山东省青岛市海慈医疗集团影像科,山东,青岛,266003 2. 青岛大学医学院附属医院影像科,山东,青岛266003 3. 山东省青岛市中心医院神经内科,山东,青岛,266042 |
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基金项目: | 山东省卫生厅和青岛市科技局基金 |
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摘 要: | 目的:探讨磁共振扩散加权成像(DWI)和灌注加权成像(PWI)在对被挽救缺血半暗带(IP)评价中的价值。方法:将制作成功的58只兔大脑中动脉闭塞(MCAO)模型随机分为永久缺血组(A组)和缺血再灌注组(B组);A组再按缺血1、3、6、12、24、48 h分组(A_1~6组),B组再按缺血1h后再灌注0、2、5、11、23、47h分组(B_(1~6)组)。然后,对各组行I)WI和PWI检查。结果:缺血再灌注组DWI像上异常信号区面积明显小于永久缺血组;缺血24h,梗死范围基本稳定。缺血1h,当表观扩散系数(ADC)比值、相对脑血容量(rCBV)比值和相对平均通过时间(rMTT)比值分别为(73.40±4.33)%、(46.83±9.89)%、1.58±0.04时,该区可能为IP;当ADC比值和rCBV比值分别低于(58.83±6.06)%和(22.87±8.19)%、rMTT比值大于1.94±0.1时,缺血脑组织将会发生不可逆性坏死。结论:DWI结合PWI能够快速、有效地评价IP。
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关 键 词: | 缺血半暗带 磁共振成像,弥散 灌注加权成像 脑缺血 再灌注 |
Diffusion and perfusion weighted imaging in quantization of ischemic penumbra in brain of rabbits |
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Affiliation: | JIANG Chuanwu, LIU Xuejun, LIU Zhenyou, et al. Department of Imaging, Hiser Hospital of Qingdao,Qingdao, 266003, China. |
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Abstract: | Objective: To discuss the value of diffusion weighted imaging (DWI) and perfusion weighted imaging (PWI) in the evaluation of ischemic penumbra (IP) salvaged. Methods: Fifty-eight successful models of middle cerebral artery occlusion (MCAO) with rabbits were randomly divided into permanent ischemic group (A group) and ischemic reperfusion group (B group). The A group was further divided into ischemic 1h, 3h, 6h, 12h, 24h, 48h groups (A1-6 group). The B group was further divided into reperfusion Oh, 2h, 5h, 11h, 23h, 47h groups (B1-4 group ) after ischemic lh. Then every group was examined with modalities including DWI and PWI. Results: The area of the abnormal signal intensity on DWI in ischemic reperfusion group was significantly smaller than that in permanent ischemic group at the same time; at ischemic 24h, the area of infarction got smoothly. At ischemic lh, if the ADC, rCBV, rMTT ratio of region of interest changed respectively during(73.40± 4.33)% ,(46.83±9.89)% and 1. 58±0.04, it might be IP, but if the ADC, rCBV ratio of region of interest changed below respectively(58.83±6.06)%,(22.87±8.19)%, and the rMTT ratio of region of interest was higher than 1.94±0.11, it would become inreverdible necrosis. Conclusion: Combined DWI with PWI could evaluate IP quickly and efficiently. |
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Keywords: | ischemic penumbra diffusion magnetic resonance imaging perfusion weighted imaging brain ischemia reperfusion |
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