| 聚乳酸基形状记忆材料对兔输卵管黏膜的影响 |
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| 引用本文： | 范玉荣,王凤英,唐帅,李勇刚,张觇宇,李玉艳,罗彦凤,梁志清. 聚乳酸基形状记忆材料对兔输卵管黏膜的影响[J]. 生殖与避孕, 2009, 29(1) |
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| 作者姓名： | 范玉荣 王凤英 唐帅 李勇刚 张觇宇 李玉艳 罗彦凤 梁志清 |
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| 作者单位： | 1. 第三军医大学两南医院妇产科,重庆,400038
2. 重庆大学生物工程学院,重庆,400044 |
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| 摘 要： | 目的:探讨聚乳酸基形状记忆输卵管避孕材料的安全性。方法:雌性大白兔15只随机分为实验组、自身对照组及空白组,分别于术后1、4、8周,取输卵管制作标本,以光镜及透射电镜观察黏膜变化。结果:实验组及自身对照组手术侧,肉眼可见材料植入体内后变短粗,后期逐渐变细小,光镜下初期可见输卵管皱襞被压缩,后皱襞内逐渐有纤维增生。电镜下上皮细胞内有异物颗粒,后期肌细胞间可见大量胶原。结论:聚乳酸基形状记忆材料植入兔输卵管后能刺激输卵管纤维组织增生,材料可降解,对机体无危害。
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| 关 键 词： | 聚乳酸基形状记忆材料 可降解 输卵管节育器 黏膜 |
Early Effects on Tubal Mucosa Using Shape-memory Polymer Based Polylactide in Rabbits |
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| Yu-rong FAN,Feng-ying WANG,Shuai TANG,Yong-gang LI,Chan-yu ZHAN,Yu-yan LI,Yan-feng LUO,Zhi-qing LIANG. Early Effects on Tubal Mucosa Using Shape-memory Polymer Based Polylactide in Rabbits[J]. Reproduction and Contraception, 2009, 29(1) |
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| Authors: | Yu-rong FAN Feng-ying WANG Shuai TANG Yong-gang LI Chan-yu ZHAN Yu-yan LI Yan-feng LUO Zhi-qing LIANG |
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| Affiliation: | 1(1. Department of Gynecology and Obstetrics; Southwest Hospital; Third Military Medical University; Chongqing; 400038) (2. College of Bioengineering; Chongqing University; 400044); |
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| Abstract: | Objective:To study the safety of shape-memory polymer based polylactide. Methods:Fifteen female rabbits were divided randomly into three groups:experimental group,self-control group and normal control group. The oviductal tissues of the rabbits were studied by light and transmission electron microscopy in 1 week,4 weeks and 8 weeks after insertion of shape-memory polymer based polylactide. Results:In the experimental group and the operation side of self-control group,it was observed that this contraception ... |
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| Keywords: | shape-memory polymer based polylactide biodegradate contraception device mucosa |
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