Further studies on the xylazine-yohimbine interaction |
| |
| Authors: | A C Freire J H Leonhardt |
| |
| Affiliation: | 1. Department of Pharmacy, Methodist University Hospital, Memphis, TN 38104;2. Department of Clinical Pharmacy, University of Tennessee Health Sciences Center (UTHSC), Memphis, TN 38163;3. Department of Pharmacy, Temple University Hospital, Philadelphia, PA 19140;4. Department of Pharmaceutical Health Services Research, University of Maryland School of Pharmacy, Baltimore, MD 21201;5. Departments of Neurology and Neurosurgery, UTHSC, Memphis, TN 38163;1. Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, CH-3010 Bern, Switzerland;2. Department of Urology, Inselspital, Bern University Hospital, University of Bern, CH-3010 Bern, Switzerland |
| |
| Abstract: | A study of the Yohimbine-blocking action upon Xylazine-ability to inhibit the abdominal contortions elicited by an intraperitoneal injection of Acetic Acid (60 mg/kg) was carried out. Xylazine (0.75 mg/kg - subcutaneously) inhibited 44% of the abdominal contortions. Such an inhibition activity was reduced to a 19% level after a previous Yohimbine treatment (1 mg/kg - intramuscularly - 30 min before). The results suggested there is a 2.9 times reduction of Xylazine affinity for CNS alpha 2 receptors, and that the antagonism between the two drugs is of a competitive nature. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
