Translocation (X;19) with involvement of the inactive X chromosome in oligoblastic granulocytic leukemia |
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| Authors: | Z Gibas L M Gibas C A Filomena J Sprandio L G Jackson |
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| Institution: | Department of Pathology, Medical College of Pennsylvania, Philadelphia. |
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| Abstract: | A 72-year-old female with metastatic breast cancer developed oligoblastic granulocytic leukemia 6 months after initiation of chemotherapy. Cytogenetic examination of the bone marrow cells revealed a balanced t(X;19)(q12;q13.3) as the sole abnormality in 50% of the metaphases. The remaining cells showed a normal female karyotype. The der(19) chromosome displayed consistent folding in the Xq13-q23 region in all metaphases, indicating involvement of the inactive X chromosome in translocation. |
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