嗜麦芽窄食单胞菌医院感染肺炎28例临床分析

目的探讨嗜麦芽窄食单胞菌的易感因素及耐药性问题。方法对2003年1月至2007年12月由嗜麦芽窄食单胞菌引起医院感染肺炎28例临床资料进行回顾性分析。结果28例患者平均住院56．43天，发生混合感染23例（82．14％），死亡8例（28．57％），侵袭性操作24例（85．71％），对多种抗生素耐药，对环丙沙星的敏感性在70％以上。结论有严重基础疾病者滥用抗生素，应用免疫抑制剂，进行侵袭性操作，住院时间长等可致嗜麦芽窄食单胞菌感染，该菌对三代头孢广泛耐药，亚胺培南天然耐药，临床可选用环丙沙星联合头孢吡肟或阿莫西林克拉维酸或头孢哌酮舒巴坦可取得一定疗效。

Clinical-analysis of 28 pneumomia patients infected with Stenotropseudomonas maltophilia

Objective To probe into the factors of infecting Stenotrophomonas maltophilia （SMA）, and the drug resistance. Methods A retrospective analysis was cpmdicted of 28 patients infected with SMA from Jan, 2003 to Dec, 2007. Results The average of the 28 patients being in the hospital was 56. 43 days. 23 patients were infected in mix （82. 14% ）, 8 patients died （28.57%） , 24 patients had invaded operations （85.71% ）. The susceptibility of the ciprofloxacin and the resistance to most ofantibiotics were over 70%. Conclusion Patients of server base diseases ill - using bacteriophage, clincal application of immunosuppresant, taking invaded operations, patients being in the hosipital for long time and so on may be risky factors for infections caused by SMA which has broad resistance to Ceftazidime, and is of natural resistance to Imipenem. Ciprofloxacin together with cefepime or amoxicillin/CA, cefoperazone/sulbattam can be very effective in clinical trials.