献血者不同献血次数间单采血小板输注疗效差异

目的探讨血小板献血者不同献血次数间单采血小板输注疗效的差异,为科学、合理、有效的献血以及血小板输注提供参考依据。方法选取2018年9-10月本院血液科血小板输注的血液病患者,追溯血小板来源,将其血小板献血者按献血次数,分为3组:第一组,为首次在本站献血小板的献血者,80例;第二组,连续献血小板献血2-9次者,32例;第三组,连续献血小板次数≥10次者,105例。统计分析数据,观察患者输注血小板前后,血小板、白细胞计数的改变,进而对血小板输注效果做比较。结果1)患者血小板输注前后白细胞平均值分别为(2.57±5.41)×10~9/L,(2.67±7.25)×10~9/L(P>0.05);男性与女性患者血小板输注有效率分别为64.03%,65.38%;年龄<18岁与>18岁患者血小板输注有效率分别为63.64%,64.67%;不同年龄段、不同性别的患者血小板输注有效率无差异(P>0.05);血小板抗体检测阴性患者有效率(84.15%)明显高于阳性(50.00%)及弱阳性(59.00%)者(P<0.05);A(58.10%)型血与B(57.81%)型血患者血小板输注有效率接近,O(74.7%)型血患者有效率明显高于A型和B型(P<0.05)。2)单采血小板献血者性别,年龄段以及献血次数对血小板输注患者有效率影响无差异(P>0.05)。3)同一患者输注不同频次献血者的血小板,各组间两两比较无差异(P>0.05)。结论血小板献血者不同献血次数间血小板输注疗效无差异。

Transfusion efficacy of fresh apheresis platelets from donations at different frequencies

Objective To investigate the transfusion efficacy of apheresis platelet concentrates from first-time/frequent apheresis donors,so as to provide references for scientific,reasonable and effective blood donation and platelet transfusion.Methods The transfusion efficacy of apheresis platelet was addressed in a cohort of 59 hematological patients acquiring platelet transfusion(received 217 transfusions)in our hospital from September to October,2018.The platelet donors were divided into three groups according to the numbers of blood donation,comprising 80 first-time apheresis donors(as the 1stgroup),32 apheresis donors who had donated successively(with internal less than one month)more than twice(range2-9)(as the 2ndgroup),and 105 apheresis donors with≥10 successive donations(as the 3rd group).Statistical analysis was conducted to observe the changes of platelet and white blood cell counts before and after platelet transfusion,and the transfusion efficacy was compared.Results 1)The mean count(×109/L)of white blood cells in patients pre-and post-transfusion was 2.5±5.41 and 2.67±7.25(P>0.05).The effective rates of platelet transfusion in male and female patients were 64.03%and 65.38%,respectively;that in patients<18 and>18 years old were 63.64%and 64.67%,respectively.There was no significant difference in transfusion efficiency among patients with different ages and genders(P>0.05).The effective rates in cross-match-negative patients(84.15%)was significantly higher than that of cross-match-positive patients(50.00%)and cross-match-weakly-positive patients(59.00%)(P<0.05).The effective rate of platelet transfusion in patients with type A(58.10%)and type B(57.81%)was close,but both were significantly lower than that of patients with type O(74.7%)(P<0.05).2)The gender,age group and numbers of blood donation of donors did not significantly affect the transfusion efficacy in patients(P>0.05).3)Transfusion efficacy in the same patient did not differ among donations at different frequencies(P>0.05).Conclusion Apheresis donation at different frequencies does not lead to effect on transfusion efficacy in patients.