益气活血法治疗慢性阻塞性肺疾病稳定期临床疗效Meta分析

目的:通过Meta分析探讨补益气活血法治疗慢性阻塞性肺疾病稳定期临床疗效。方法:计算机检索CNKI、VIP、WanFang、Cochrane Library、EMbase、PubMed等各个数据库,获取建库至2020年4月相关文献,用Excel 2010软件进行资料提取后,Rev Man5.3软件进行Meta分析。结果:最后纳入19篇文献,18篇中文,1篇英文,共计COPD患者1465例,经分析后Meta结果显示:与对照组比较,加用益气活血法后在肺功能得到改善,FEV1%:(MD=6.15,95%CI3.79,8.51],Z=5.10,P<0.0001).FEV1/FVC:(MD=4.06,95%CI2.97,5.15],Z=7.32,P<0.00001)。中医证候好转(MD=-1.54,95%CI-2.01,-1.06],Z=6.31,P<0.00001);生活质量提高(MD=-5.88,95%CI-7.86,-3.90],Z=4.62,P<0.00001);6分钟步行实验结果好转(MD=44.41,95%CI20.29,68.53],Z=3.61,P=0.0003);呼吸困难程度(mMRC)减轻(MD=-0.43,95%CI-0.79,-0.06],Z=2.31,P=0.02);全血黏度降低(MD=-0.99,95%CI-1.46,-0.52],Z=4.11,P<0.001);临床疗效增强(MD=1.19,95%CI1.10,1.30],Z=4.26,P<0.0001)。结论:益气活血法在治疗COPD较常规疗法中能够提高临床疗效。由于本文纳入Meta分析的样本数有限,临床研究质量不高,需开展更多大样本、设计严谨的多中心随机对照试验进行验证。

Meta-analysis of Clinical Efficacy of Yiqi Huoxue Method in Treating Chronic Obstructive Pulmonary Disease

Objective:To explore the clinical efficacy of the treatment of chronic obstructive pulmonary disease in stable phase with the method of invigorating Qi and activating blood through Meta analysis.Methods:Computer search of various databases including CNKI,VIP,WanFang,Cochrane Library,EMbase,PubMed,etc.,to obtain relevant documents from the establishment of the library to April 2020,use Excel 2010 software for data extraction,Rev Man5.3 software for meta-analysis.Results:Finally,19 articles,18 articles in Chinese and 1 article in English were included.A total of 1465 COPD patients were included.After analysis,the Meta results showed that:compared with the control group,the lung function was improved after the addition of Qi and blood circulation method,FEV1%:(MD=6.15,95%CI3.79,8.51],Z=5.10,P<0.0001).FEV1/FVC:(MD=4.06,95%CI2.97,5.15],Z=7.32,P<0.00001).TCM syndromes improved (MD=-1.54,95%CI-2.01,-1.06],Z=6.31,P<0.00001);quality of life improved (MD=-5.88,95%CI-7.86,-3.90],Z=4.62,P<0.00001);6-minute walk test results improved (MD=44.41,95%CI20.29,68.53],Z=3.61,P=0.0003);dyspnea (mMRC) was reduced (MD=-0.43,95%CI-0.79,-0.06],Z=2.31,P=0.02);decreased whole blood viscosity (MD=-0.99,95%CI-1.46,-0.52],Z=4.11,P<0.001);Clinical efficacy is enhanced (MD=1.19,95%CI1.10,1.30],Z=4.26,P<0.0001).Conclusion:The method of replenishing Qi and activating blood can improve the clinical efficacy in the treatment of COPD compared with conventional therapy.Due to the limited number of samples included in the meta-analysis in this article,the quality of clinical research is not high,and more large-sample,rigorously designed multi-center randomized controlled trials are needed for verification.