| 重组人促红素对老年慢性肾衰病人氧自由基及抗氧化酶活性的影响 |
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| 引用本文： | 杜玉君,李秀江,徐学明. 重组人促红素对老年慢性肾衰病人氧自由基及抗氧化酶活性的影响[J]. 中国老年学杂志, 1999, 19(5): 0 |
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| 作者姓名： | 杜玉君 李秀江 徐学明 |
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| 作者单位： | 白求恩医科大学第一临床学院肾内科!长春130021 |
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| 摘 要： | 目的 探讨重组人促红素（ｒ Ｈ Ｅ Ｐ Ｏ ）对慢性肾衰患者体内氧自由基及抗氧化酶活性的影响。方法 测定 １９ 例老年慢性肾衰尿毒症期患者 ｒ Ｈ Ｅ Ｐ Ｏ 治疗前后血浆 Ｍ Ｄ Ａ 、 Ｓ Ｏ Ｄ 及红细胞 Ｇ Ｓ Ｈ Ｐｘ 含量。结果 ｒ Ｈ Ｅ Ｐ Ｏ 治疗后慢性肾衰病人 Ｍ Ｄ Ａ 含量降低， Ｓ Ｏ Ｄ 、 Ｇ Ｓ Ｈ Ｐｘ 活性升高。结论 ｒ Ｈ Ｅ Ｐ Ｏ 纠正肾性贫血同时，可清除体内氧自由基，提高抗氧化酶活性。
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| 关 键 词： | 重组人促红素 氧自由基 超氧化物歧化酶 谷胱甘肽过氧化物酶 |
The effects of recombinanthuman erythropoietin(rH-EPO) on oxygen free radical levels and the activities ofantioxidases in chronic renal failure patients |
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| Du Yujun, Li Xiujiang, Xu XuemingThe st Affiliated Hospital of Norman Bethune University of Medical Science, Changchun. The effects of recombinanthuman erythropoietin(rH-EPO) on oxygen free radical levels and the activities ofantioxidases in chronic renal failure patients[J]. Chinese Journal of Gerontology, 1999, 19(5): 0 |
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| Authors: | Du Yujun Li Xiujiang Xu XuemingThe st Affiliated Hospital of Norman Bethune University of Medical Science Changchun |
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| Affiliation: | Du Yujun, Li Xiujiang, Xu XuemingThe 1 st Affiliated Hospital of Norman Bethune University of Medical Science, Changchun130021 |
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| Abstract: | Objective To study the effects of rH EPO on the levels oxygen free radicals and the activities of antioxidases in chronic renal failure patients(CRF).Methods Contents of MDA and SOD in plasma, GSH Px in erythrocytes in CRF patients were measured.Results The level of MDA was higher, the activitie of SOD and GSH Px, was lower in CRF patients as compared with that in healthy controls. After twelve weeks of the treatment with rH EPO, the levels of MDA decreased, the activities of SOD and GSH Px incereased.Conclusions Decrease the MDA and increase the activities of SOD and GSH Px can be acheived through improving the anemia of CRF patients treated with rH EPO. |
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| Keywords: | rH EPO MDA SOD GSH Px |
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