快速进展性牙周炎牙龈组织中单核/巨噬细胞浸润与Mcp-1表达

目的 研究快速进展性牙周炎牙龈组织中的单核／巨噬细胞浸润与单核细胞趋化蛋白１（ｍｏｎｏｃｙｔｅ ｃｈｅｍｏａｔｔｒａｃｔａｎｔ ｐｒｏｔｅｉｎ－１，ＭＣＰ－１）表达有无异常变化。方法 采用免疫组织化学ＳＰ染色法，取１４例快速进展性牙周炎、６例慢性牙周炎和６例健康牙龈组织，分别用抗ＣＤ１４、ＣＤ６８单克隆抗体检测牙龈组织中的单核／巨噬细胞，用ＭＣＰ－１多克隆抗测于龈组织中ＭＣＰ－１的表达。结果 快速

Infiltration of monocytes/macrophages and expression of monocyte chemoattractant protein-1 in gingival tissues from patients with rapidly progressive periodontitis

OBJECTIVE: To find if there was any difference in monocytes/macrophages infiltration and monocyte chemoattractant protein-1(MCP-1) expression between rapidly progressive periodontitis (RPP) and adult periodontitis (AP) tissues. METHODS: Inflamed gingival specimens (20) were obtained from RPP(14) and AP(6) patients, and specimens from clinically healthy subjects (H,6) as control. The monocytes/macrophages and MCP-1 expression were detected by immuno-histochemistry SP assay with antibodies against CD14 and CD68, and rabbit anti-MCP-1 antibody. RESULTS: There were no differences in the mean counts (+/- SD) of monocytes/macrophages and MCP-1 positive cells between RPP and AP groups. CONCLUSION: Though rapid and severe periodontal destruction occurs in RPP, there is no differences in monocytes/macrophages infiltration and MCP-1 expression in gingival tissues between rapidly progressive periodontitis and adult periodontitis patients.