佐匹克隆与奥沙西泮治疗失眠症对照研究

目的：探讨佐匹克隆与奥沙西泮治疗失眠症患者的临床疗效和安全性。方法将100例失眠症患者随机分为研究组51例，对照组49例，研究组口服佐匹克隆治疗，对照组口服奥沙西泮治疗，观察4周。于治疗前后采用睡眠障碍评定量表评定临床疗效，副反应量表评定不良反应。结果治疗4周末，研究组显效率86．3％、总有效率96．1％，对照组分别为77．6％、93．9％，两组临床疗效比较差异无显著性（χ2＝1．31，P＞0．05）。研究组不良反应发生率为9．8％，对照组为42．8％，研究组显著低于对照组（χ2＝14．19，P＜0．01）。结论佐匹克隆与奥沙西泮治疗失眠症疗效显著，总体疗效相当，但佐匹克隆安全性更高，依从性更好，更适用于初次就诊的失眠症患者。

A control study of zopiclone vs .oxazepam in the treatment of i nsomnia

Objective To explore the efficacy and safety of zopiclone and oxazepam in the treatment of in-somnia .Methods A total of 100 insomnia patients were randomly divided into research （n=51） and con-trol group （n=49） ,research took orally zopiclone and control group did oxazepam for 4 weeks .Efficacies were assessed with the Sleep Dysfuntion Rating Scale （SDRS） before and after treatment and adverse reac-tions with the Treatment Emergent Symptom Scale （TESS） .Results At the end of the 4th week obvious and total effective rate were respectively 86 .3% and 96 .15 in research and 77 .6% and 93 .9% in control group ,which showed no significant differences （χ2 =1 .31 ,P〉0 .05） .The rate of adverse reactions was 9 . 8% in research and 42 .8% in control group ,the former was significantly lower than the latter （χ2 =14 .19 ,P〈0 .01） .Conclusion Both zopiclone and oxazepam have an evident and equivalent effect in in-somnia ,but the former has higher safety and better compliance and is more suitable for first-visiting in-somnia patients .