达英-35治疗多囊卵巢综合征的临床观察

目的观察达英-35治疗多囊卵巢综合征（PCOS）并胰岛素抵抗患者的临床效果。方法选取20例合并胰岛素抵抗的PCOS患者,均进行达英-35口服治疗,对治疗前、后的临床症状以及内分泌生化指标统计分析。结果患者治疗后与治疗前比较,在体质量指数（BMI）、腰围与臀围比（WHR）方面无明显差异;睾酮（T）、黄体生成素（LH）、空腹血糖/空腹胰岛素（GIR）明显降低及性激素结合蛋白（SHBG）显著升高（P〈0.05）,卵泡刺激素（FSH）、三酰甘油（TG）、血清胰岛素样生长因子-1（IGF-1）、C反应蛋白（CRP）无明显变化。结论达英-35治疗多囊卵巢综合征,能有效控制高雄激素血症,明显改善临床症状,不能提高胰岛素敏感性。

Clinical observation on effect of Diane-35 in the treatment of polycystic ovary syndrome

ObjectiveTo observe the efficacy of Diane-35 in the treatment of polycystic ovary syndrome.MethodsThere were 20 cases of polycystic ovary syndrome and insulin resistance in patients who received treatment with Diane-35, and compared the changes of the clinical symptoms and biochemical indicators of endocrine after 6 months.ResultsCompared with prior treatment, there was no significant difference about the BMI and WHR, the biochemical indicators of endocrine, T, LH and GIR significantly decreased, and SHBG significantly increased after treatment（P〈0.05）, but there was no significant difference about TG, CRP and IGF-1. ConclusionDiane-35 for treatment of polycystic ovary syndrome can effectively control hyperandrogenism, significant improve clinical symptoms,but can not improve insulin sensitivity.