西酞普兰联合认知疗法治疗产后抑郁症对照研究

目的：探讨西酞普兰联合认知疗法治疗产后抑郁症的临床疗效和安全性。方法将64例产后抑郁症患者随机分为两组，每组32例，两组均晨口服西酞普兰治疗，研究组联合认知疗法治疗，观察6周。于治疗前后采用汉密顿抑郁量表评定临床疗效，副反应量表评定不良反应。结果治疗各时段研究组汉密顿抑郁量表评分显著低于对照组（P＜0．05），显效时间显著快于对照组（ t＝3．12，P＜0．01）；治疗6周末两组显效率、总有效率及不良反应发生率比较差异均无显著性（P＞0．05）。结论西酞普兰联合认知疗法治疗产后抑郁症起效快，疗效显著，安全性高，显著优于单用西酞普兰治疗。

A control study of citalopram combined with cognitive therapy in postnatal depression

Objective To explore the efficacy and safety of citalopram combined with cognitive therapy in postnatal depression （PD） .Methods Sixty-four PD patients were randomly di-vided into two groups of 32 ones each ,both groups took orally citalopram in the morning ,research group was plus cognitive therapy for 6 weeks .Clinical efficacies were assessed with the Hamilton Depression Scale （HAMD） before and after treatment and adverse reactions with the Treatment Emergent Symptom Scale （TESS） .Results The HAMD score in each period was significantly lower （P〈0 .05） and effectual time shorter （t=3 .12 ,P〈0 .01） in research than in control group ;there were no significant group differ-ence in obvious and total effective rate as well as incidences of adverse reactions （P〉0 .05） .Conclusion Citalopram combined with cognitive therapy takes effect more rapidly and has an evident effect and higher safety compared with single-use citalopram in the treatment of postnatal depression .