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Synthesis,QSAR studies,and metabolic stability of novel 2‐alkylthio‐4‐chloro‐N‐(5‐oxo‐4,5‐dihydro‐1,2,4‐triazin‐3‐yl)benzenesulfonamide derivatives as potential anticancer and apoptosis‐inducing agents
Authors:Beata ?o?nowska  Jaros?aw S?awiński  Aneta Pogorzelska  Krzysztof Szafrański  Anna Kawiak  Grzegorz Stasi?oj?  Mariusz Belka  Joanna Zielińska  Tomasz B?czek
Institution:1. Department of Organic Chemistry, Medical University of Gdańsk, Gdańsk, Poland;2. Department of Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland;3. Laboratory of Human Physiology, Medical University of Gdańsk, Gdańsk, Poland;4. Laboratory of Cell Biology, Department of Medical Biotechnology, Intercollegiate Faculty of Biotechnology UG‐MUG, Medical University of Gdańsk, Gdańsk, Poland;5. Department of Pharmaceutical Chemistry, Medical University of Gdańsk, Gdańsk, Poland
Abstract:
Keywords:anticancer  apoptosis  benzenesulfonamide  metabolic stability  mitochondrial membrane potential  QSAR  synthesis
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