An expedient synthesis of N‐(1‐(5‐mercapto‐4‐((substituted benzylidene)amino)‐4H‐1,2,4‐triazol‐3‐yl)‐2‐phenylethyl)benzamides as jack bean urease inhibitors and free radical scavengers: Kinetic mechanism and molecular docking studies |
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Authors: | Aamer Saeed Fayaz Ali Larik Pervaiz Ali Channar Haroon Mehfooz Mohammad Haseeb Ashraf Qamar Abbas Mubashir Hassan Sung‐Yum Seo |
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Affiliation: | 1. Department of Chemistry, Quaid‐I‐Azam University, Islamabad, Pakistan;2. Department of Biological Sciences, College of Natural Sciences, Kongju National University, Gongju, Chungnam, Korea |
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Abstract: | In this study, some new azomethine‐triazole hybrids 5a–5l derived from N‐benzoyl‐L‐phenylalanine were synthesized and characterized. The synthesized compounds showed first‐rate, urease inhibition, and compounds 5c and 5e were found to be most effective inhibitors with 0.0137 ± 0.00082 μm and 0.0183 ± 0.00068 μm , respectively (thiourea 15.151 ± 1.27 μm ). The kinetic mechanism of urease inhibition revealed the compounds 5c and 5e to be non‐competitive inhibitors, whereas compounds 5d and 5j were found to be of mixed‐type inhibitors. Docking studies also indicated better interaction patterns with urease enzyme. The results of enzyme inhibition, kinetic mechanism and molecular docking suggest that these compounds can serve as lead compounds in the design of more effective urease inhibitors. |
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Keywords: | antioxidant activity drug‐design kinetic mechanism molecular docking triazolyl benzamides urease inhibitors |
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