益胃法对初老雌性大鼠CFS模型中枢单胺类神经递质代谢影响的实验研究

目的：观察“益胃法”对初老雌性大鼠CFS模型动物中枢单胺类神经递质代谢影响。方法：4-6月龄雌性大鼠为正常对照组；10～12月龄，阴道细胞学表现动情期延长的雌性大鼠作为初老大鼠模型，采用复合刺激法造模。模型动物随机分为：（1）空白对造组、（2）益胃汤高剂量组、（3）益胃汤中剂量组、（4）益胃汤低剂量组、（5）氟西汀组。灌药4周后，断头处死，取脑组织进行检测。结果：益胃汤通过调节单胺类递质降解的主要酶MAO的含量，使MAO含量减低，使NE、5-HT含量升高；DA含量呈降低趋势。结论：益胃汤可能通过改善中枢神经递质代谢从而促进疲劳状态的恢复，提高学习记忆的作用。

Study on the Influence of "Yiweifa" to the Metabolism of Central Monoamine Neurotransmitter of the Primary Senile CFS Rat

Objects： Study on the ＂Yiweifa＂ to know the metabolism of central monoanmine neurotransmitter of the primary senile CFS rat.Methods： 4-6 months old SD female rats were set to be normal control group and 10-12 months old SD female rats whose oestrus elongation were set as primary senile female rat model. Applying complex stimulate factors to make CFS rat model. Animal models were devided into 5 groups randomly as foUowing： Model control group, High dose Yiweitang group, Middle dose Yiweitang group, Low dose Yiweitang group, Fluoxetine tablets group. The intervention period was 4 weeks. The brain was treated by Immune histochem- istry method. Results： Yiweitang decrease the MAO content, increase the NE and 5 - HT content and reduces the DA content, thus regulate the metabolism of central monoamine neurotransmitter. Conclusions： The results showed that Chinese Traditional Medicine yiweitang＇possibly improves the metabolism of the central monoamine neurotransmitter, alleviate the condition of ＂chronic fatigue＂ and improve the memory.