益气养阴法对气阴两虚型慢性尿酸性肾病患者红细胞CR1分子基因型及数量表达与黏附活性的影响

目的:探讨益气养阴法对气阴两虚型慢性尿酸性肾病(CUAN)患者红细胞CR1分子基因型及数量表达、黏附活性的影响.方法:先检测30例气阴两虚型CUAN患者的红细胞CR1分子基因型及数量表达、黏附活性,并与健康人比较;再将气阴两虚型CUAN患者分为中西组与对照组,检测治疗后红细胞CR1分子基因型及数量表达、黏附活性.结果:气阴两虚型CUAN患者与健康人的红细胞CR1分子基因型无统计学差异(P＞0.05).气阴两虚型CUAN的红细胞CR1数量表达、黏附活性明显低于健康人(P＜0.01).治疗前后中西组与对照组的红细胞CR1分子基因型无变化,中西组的红细胞CR1数量表达、黏附活性较对照组明显升高,两组之间有统计学差异(P<0.05).结论:益气养阴法对气阴两虚型慢性尿酸性肾病患者红细胞CR1数量表达、黏附活性有明显影响.

Effect of Supplementing Qi and Nourishing Yin on Erythrocytes CR1 Genomic Density and its Quantitative Expression and Adherent Activity in Chronic Uric Acid Nephropathy with Deficiency of both Qi and Yin

Objective:To study the effect of Supplementing Qi and Nourishing Yin on erythrocytes CR1 genomic density and quantitative expression and adherent activity of chronic uric acid nephropathy with Deficiency of both Qi and Yin.Methods:Patients were divided into 4 groups: Before treatment group; Western medicine group; Chinese western medicine group and Control group.Erythrocytes CR1 genomic density polymorphism and its quantitative expression and adherent activity were measured.Results:Erythrocytes CR1 genomic density polymorphism of before treatment group, western medicine group, Chinese western medicine group and control group had no significant difference(P>0.05). Erythrocytes CR1 quantitative expression and adherent activity of before treatment group were significantly lower than that of control group(P< 0.01). After treatment, erythrocytes CR1 quantitative expression and adherent activity in Chinese western medicine group were significantly higher than that of western medicine group(P<0.05).Conclusion:Supplementing Qi and Nourishing Yin have significantly effect on erythrocyte CR1 quantitative expression and adherent activity in chronic uric acid nephropathy with Deficiency of both Qi and Yin.