Cardiovascular complications versus adequacy and peritoneal transport characteristics in CAPD patients

The aim of the study was a comparative analysis of cardiovascular status and basic parameters of adequacy and peritoneal transport in CAPD patients. 15 persons treated with CAPD over 2 years were included in the study. Cardiovascular status at the beginning and at the end of observation was assessed using the own scoring. Patients were divided into 3 groups of cardiovascular disease (CVD) progression: group I--without CDV progression, group II--with moderate CVD progression and group III--with severe CVD progression. The biochemical factors of CVD risk at the beginning and the end of observation were also measured. The adequacy and peritoneal transport parameters (Kt/V, CrCl and D/P creatinine) were calculated. Group I was characterized by the highest average Kt/V value as well as percent of Kt/V studies > or = 2.0. These values were significantly lower in group II and III. The average CrCl value was highest in group I and lowest in group II. The relatively high, significant reverse correlation between Kt/V and CVD scoring at the end of observation was revealed. Lower but significant correlation between serum albumin and CVD scoring at the end of observation was also established. The analysis of the link between CVD progression and changes of transport characteristics in studied population revealed the highest peritoneal transport in group III from the beginning of observation. The undesirable change of peritoneal transport characteristics was stated in group II and III. The results of our study let us to conclude that in observed population only high values of adequacy parameters reduced the risk of CVD progression. Kt/V seems to be better predictor of CVD progression than CrCl. The risk of CVD in CAPD patients is probably higher due to increase of peritoneal permeability.