Microscopic colitis patients have increased proportions of Ki67+ proliferating and CD45RO+ active/memory CD8+ and CD4+8+ mucosal T cells |
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| Institution: | 1. School of Health and Medical Sciences, Örebro University, Örebro, Sweden;2. Dept. of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden;1. Division of Rheumatology, Mount Sinai Hospital, University of Toronto, The Joseph and Wolf Lebovic Building, 60 Murray St, Ste 2-220, Toronto, Ontario, Canada M5T 3L9;2. Division of Rheumatology, McMaster University, Hamilton, Ontario, Canada;3. Division of Rheumatology, University of British Columbia, Vancouver, British Columbia, Canada;4. Division of Rheumatology, St. Joseph’s Health Care, London, Ontario, Canada;5. Department of Biostatistics, University of South Florida, Tampa, FL;6. Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH;7. Division of Rheumatology, University of Utah, Salt Lake City, UT;8. Division of Rheumatology, University of Pennsylvania, Philadelphia, PA;9. Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA;10. The Vasculitis Center, Section of Rheumatology, Boston University School of Medicine, Boston, MA;11. Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA;12. Division of Rheumatology, Johns Hopkins University, Baltimore, MD;13. Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN;14. Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, MN;15. Division of Gastroenterology, University of Toronto-Inflammatory Bowel Disease Clinic, Toronto, Ontario, Canada;1. Hospitality and Tourism Management, Walker College of Business, Appalachian State University, 4078 Peacock Hall, Boone, NC 28608, USA;2. School of Hotel, Restaurant, and Tourism Management, Center of Economic Excellence (CoEE) and Tourism and Economic Development, Coliseum Room 1011, Columbia, SC 29208, USA;3. Recreation and Leisure Studies, Center for Sustainable Tourism, East Carolina University, Belk Building 1408, Greenville, NC 27858, USA;4. Retailing and Tourism Management, College of Agriculture, Food and Environment, University of Kentucky, 120 Erikson Hall, Lexington, KY 40506, USA;1. Ifo Institute, Germany;2. University of Munich, Ifo Institute, CESifo, Germany;3. University of Exeter, UK |
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| Abstract: | BackgroundCollagenous colitis (CC) and lymphocytic colitis (LC) are chronic inflammatory bowel disorders of unknown etiology. This study investigated phenotypic characteristics of the mucosal lymphocytes in CC and LC.MethodsLamina propria and intraepithelial lymphocytes (LPLs, IELs) isolated from mucosal biopsies from CC (n = 7), LC (n = 6), as well as LC or CC patients in histopathological remission, (LC-HR) (n = 6) and CC-HR (n = 4) and non-inflamed controls (n = 10) were phenotypically characterized by four-color flow cytometry.ResultsThe proportions of CD8+ IELs were increased in CC and LC (p < 0.01) compared to controls. Increased proportions of CD45RO+CD8+ IELs and LPLs were observed in LC and even more in CC patients (p < 0.01). Both CC (p < 0.05) and LC patients had elevated proportions of CD4+8+ IELs and LPLs compared to controls. The proportions of CD45RO+ cells were increased in CD4+8+ IELs and LPLs (p < 0.05) in CC and LC patients compared to controls. Both CC (p < 0.05) and LC patients had higher proportions of Ki67+CD8+ IELs and LPLs compared to controls.In contrast, decreased proportions of CD4+ LPLs were observed in CC and LC as well as CD4+ IELs in LC compared to controls. Increased proportions of Ki67+CD4+ IELs and LPLs (p < 0.05) were observed in CC and LC patients.CC-HR but not LC-HR patients demonstrated normalized proportions of both IELs and LPLs compared to CC and LC patients respectively.ConclusionLC and CC patients have differences in mucosal lymphocyte subsets, with increased proportions of Ki67+ and CD45RO+ CD8+ and CD4+8+ mucosal T cells. |
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