| Abstract: | The emergence of ganciclovir (GCV) resistance during the treatment of humancytomegalovirus (HCMV) infection is a serious clinical challenge, and is associatedwith high morbidity and mortality. In this case report, we describe the emergence oftwo consecutive mutations (A594V and L595W) related to GCV resistance in a patientwith HCMV retinitis and long-term HIV progression after approximately 240 days of GCVuse. Following the diagnosis of retinitis, the introduction of GCV did not result inviral load reduction. The detected mutations appeared late in the treatment, and wepropose that other factors (high initial HCMV load, previous GCV exposure, lowCD4+ cell count), in addition to the presence of resistance mutations,may have contributed to the treatment failure of HCMV infection in this patient. |
