单细胞测序技术在头颈部恶性肿瘤中的研究与发展

单细胞测序是针对单个细胞的遗传信息进行测序,能更好地认识细胞之间的差异,解决了普通测序带来的异质性问题。头颈部恶性肿瘤已经成为癌症相关疾病死亡的第六大病因,单细胞测序技术应用于揭示头颈部恶性肿瘤的异质性、描述头颈部恶性肿瘤的微环境、评估头颈部恶性肿瘤的侵袭、转移和评价治疗效果、评估治疗抵抗、探究循环肿瘤细胞的作用等方面,对头颈部恶性肿瘤发生发展的研究和个体化治疗方案的探索有着巨大的推动作用。本综述旨在概述单细胞测序的机理和意义,总结其在头颈部恶性肿瘤中的研究进展。

Research and development of single-cell sequencing technology in head and neck malignant tumors

Single cell sequencing is to sequence the genetic information of a single cell,which can better understand the differences amongst cells and solve the heterogeneity problem caused by ordinary sequencing.Head and neck malignant tumors have become the sixth leading cause of death from cancer-related diseases.Single-cell sequencing technology is used to reveal the heterogeneity of head and neck malignant tumors,describe the microenvironment of head and neck malignant tumors,and evaluate the invasion and metastasis of head and neck malignant tumors.The evaluation of therapeutic effects and treatment resistance and exploration of the role of circulating tumor cells have greatly promoted the research on the occurrence and development of head and neck malignant tumors and the exploration of individualized treatment options.This review aims to outline the mechanism and significance of single-cell sequencing,and summarize its research progress in malignant tumors of head and neck.