| MCM蛋白在消化系统肿瘤的研究进展 |
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| 引用本文： | 商昌权,李国东,魏九峰,刘明.MCM蛋白在消化系统肿瘤的研究进展[J].实用肿瘤学杂志,2021,35(5):431-435. |
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| 作者姓名： | 商昌权 李国东 魏九峰 刘明 |
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| 作者单位： | 1.哈尔滨医科大学附属第四医院普外科(哈尔滨 150001);2.哈尔滨医科大学附属第二医院普外科 |
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| 基金项目： | 国家自然科学基金面上项目(编号:82072673) |
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| 摘 要： | 微小染色体维持(Minichromosome maintenance,MCM)蛋白是真核细胞DNA复制过程中的重要物质,参与了DNA复制的始动及延长。由于某些因素导致MCM蛋白表达异常时,静止期的细胞开始新的细胞周期,DNA发生异常复制,细胞开始无限增殖,致使肿瘤的产生,因此MCM蛋白被认为是一种新的肿瘤标志物。消化系统肿瘤与MCM蛋白关系密切,探索MCM蛋白可以为消化系统肿瘤的诊断和治疗带来新的方法。
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| 关 键 词： | 微小染色体维持蛋白 消化系统肿瘤 肿瘤标志物 |
| 收稿时间： | 2020-11-17 |
Research progress of MCM protein in digestive system tumors |
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| SHANG Changquan,LI Guodong,WEI Jiufeng,LIU Ming.Research progress of MCM protein in digestive system tumors[J].Journal of Practical Oncology,2021,35(5):431-435. |
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| Authors: | SHANG Changquan LI Guodong WEI Jiufeng LIU Ming |
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| Institution: | 1. Department of General Surgery,The Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,China;2. Department of General Surgery,The Second Affiliated Hospital of Harbin Medical University |
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| Abstract: | Minichromosome maintenance(MCM)proteins are important substances in the DNA replication process of eukaryotic cells,and are involved in the initiation and elongation of DNA replication.When certain factors cause the abnormal expression of MCM protein,cells in the quiescent phase start a new cell cycle,abnormal DNA replication occurs,and cells begin to proliferate indefinitely,resulting in tumorigenesis.Therefore,MCM protein is considered as a new tumor marker.Digestive system tumors are closely related to MCM protein.Exploring the MCM protein can bring new methods for the diagnosis and treatment of digestive system tumors. |
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| Keywords: | Minichromosome maintenance protein Digestive system tumor Tumor marker |
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