Malignant giant cell tumors of the tendon sheath of the right hip: A case report |
| |
Authors: | Wen-Peng Huang Ge Gao Qi Yang Zhao Chen Yong-Kang Qiu Jian-Bo Gao Lei Kang |
| |
Affiliation: | Wen-Peng Huang, Qi Yang, Zhao Chen, Yong-Kang Qiu, Lei Kang, Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, ChinaGe Gao, Department of Medical Imaging, Peking University First Hospital, Beijing 100034, ChinaJian-Bo Gao, Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China |
| |
Abstract: | BACKGROUNDMalignant giant cell tumor of the tendon sheath (MGCTTS) is an extremely rare malignant tumor originating from synovial and tendon sheath tissue with highly aggressive biological behavior and a high rate of local recurrence and distant metastasis which should be considered a highly malignant sarcoma and managed aggressively. How to systemically treat MGCTTS remains a challenge. In this case, a patient with MGCTTS suffered a recurrence after 2 surgical resections received adjuvant chemotherapy and radiation therapy, but the treatment outcome remained poor. More clinical trials and better understanding of the biology and molecular aspects of this subtype of sarcoma are needed while novel medicines should be developed to efficiently target particular pathways.CASE SUMMARYA 52-year-old man presented with persistent dull pain in the right groin accompanied by limited right hip motion starting 6 mo ago. Two months before his attending to hospital, the patient''s pain worsened, presenting as severe pain when standing or walking, limping, and inability to straighten or move the right lower extremity. Surgical excision was performed and MGCTTS was confirmed by pathology examination. Two recurrences occurred after surgical resection, moreover, the treatment outcome remained poor after adjuvant chemotherapy and radiation therapy. The patient died only 10 mo after the initial diagnosis.CONCLUSIONMGCTTS is characterized by a joint mass with pain and limited motion. It typically grows along the tendons and infiltrated into the surrounding muscle and bone tissue, with a stubborn tendency to relapse, as well as pulmonary metastasis. Radically surgical resection provides a choice of treatment whereas post-operation care should be taken to preserve the function of the joint. Chemotherapy and radiotherapy can be used as alternative treatments when radical resection cannot be performed. |
| |
Keywords: | Malignant Tenosynovial giant cell tumor Recurrence Magnetic resonance imaging Bone scintigraphy Treatment X-ray computed tomography Case report |
|
| 点击此处可从《World Journal of Clinical Cases》浏览原始摘要信息 |
|