Vascular and plaque imaging with ultrasmall superparamagnetic particles of iron oxide |
| |
| Authors: | Shirjel R. Alam Colin Stirrat Jennifer Richards Saeed Mirsadraee Scott I. K. Semple George Tse Peter Henriksen David E. Newby |
| |
| Affiliation: | .Centre for Cardiovascular Science, The University of Edinburgh, The Chancellor’s Building, Little France Crescent, Edinburgh, EH16 5SA UK ;.Department of Cardiology, Royal Infirmary of Edinburgh, Edinburgh, EH16 5SA UK ;.Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, EH16 5SA UK ;.Department of Radiology, Royal Infirmary of Edinburgh, Edinburgh, EH16 5SA UK ;.MRC Centre for Inflammation Research, The University of Edinburgh, Edinburgh, EH16 5SA UK |
| |
| Abstract: | Cardiovascular Magnetic Resonance (CMR) has become a primary tool for non-invasive assessment of cardiovascular anatomy, pathology and function. Existing contrast agents have been utilised for the identification of infarction, fibrosis, perfusion deficits and for angiography. Novel ultrasmall superparamagnetic particles of iron oxide (USPIO) contrast agents that are taken up by inflammatory cells can detect cellular inflammation non-invasively using CMR, potentially aiding the diagnosis of inflammatory medical conditions, guiding their treatment and giving insight into their pathophysiology. In this review we describe the utilization of USPIO as a novel contrast agent in vascular disease. |
| |
| Keywords: | USPIO Nanoparticles CMR Cardiovascular imaging Inflammation Macrophage |
|
|
