Characterization of focal pancreatic lesions using normalized apparent diffusion coefficient at 1.5-Tesla: Preliminary experience |
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| Institution: | 1. Department of Abdominal Imaging, hôpital Lariboisière, Assistance Publique–Hôpitaux de Paris, 2, rue Ambroise-Paré, 75010 Paris, France;2. Université Paris-Diderot, Sorbonne Paris Cité, 10, avenue de Verdun, 75010 Paris, France;3. Department of Radiology, centre hospitalier, hôpital Robert-Debré, 11, boulevard Pasteur, 51092 Reims cedex, France;4. Department of Digestive Diseases, hôpital Lariboisière, Assistance Publique–Hôpitaux de Paris, 2, rue Ambroise-Paré, 75010 Paris, France;5. Surgical Oncologic & Digestive Unit, hôpital Lariboisière, Assistance Publique–Hôpitaux de Paris, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France;6. UMR INSERM 965-Paris 7 “Angiogenèse et recherche translationnelle”, 2, rue Ambroise-Paré, 75010 Paris, France |
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| Abstract: | PurposeTo compare the capabilities of apparent diffusion coefficient (ADC) and normalized ADC using the pancreatic parenchyma as reference organ in the characterization of focal pancreatic lesions.Patients and methodsThirty-six patients with focal pancreatic lesions (malignant, n = 18; benign tumors, n = 10; focal pancreatitis, n = 8) underwent diffusion-weighted MR imaging (DWI) at 1.5-Tesla using 3 b values (b = 0, 400, 800 s/mm2). Lesion ADC and normalized lesion ADC (defined as the ratio of lesion ADC to apparently normal adjacent pancreas) were compared between lesion types using nonparametric tests.ResultsSignificant differences in ADC values were found between malignant (1.150 × 10 ?3 mm2/s) and benign tumors (2.493 × 10?3 mm2/s) (P = 0.004) and between benign tumors and mass-forming pancreatitis (1.160 × 10?3 mm2/s) (P = 0.0005) but not between malignant tumors and mass-forming pancreatitis (P = 0.1092). Using normalized ADC, significant differences were found between malignant tumors (0.933 × 10?3 mm2/s), benign tumors (1.807 × 10?3 mm2/s) and mass-forming pancreatitis (0.839 × 10?3 mm2/s) (P < 0.0001).ConclusionOur preliminary results suggest that normalizing ADC of focal pancreatic lesions with ADC of apparently normal adjacent pancreatic parenchyma provides higher degrees of characterization of focal pancreatic lesions than the conventional ADC does. |
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