Fecal chromogranins and secretogranins are increased in patients with ulcerative colitis but are not associated with disease activity |
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| Institution: | 1. Dept. of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Sweden;2. Dept. of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Sweden;3. Dept. of Internal Medicine, Södra Älvsborgs Hospital, Borås, Sweden;4. Dept. of Medical Sciences, Uppsala University, Sweden;1. IBD Unit, Gastroenterology and Hepatology Service, Puerta de Hierro University Hospital, Majadahonda, Madrid, Spain;2. Dermatology Service, Puerta de Hierro University Hospital, Majadahonda, Madrid, Spain;1. Gastroenterology and Endoscopy Unit, A.R.N.A.S. Civico-Di Cristina-Benfratelli Hospital, Palermo, Italy;2. Unit of Internal Medicine, Ospedali Riuniti “Villa Sofia-Cervello”, Palermo, Italy;1. Colorectal Surgery Unit, Cajuru University Hospital, Catholic University of Parana, Curitiba, PR, Brazil;2. Inflammatory Bowel Disease Center, Yokkaichi Social Insurance Hospital, Yokkaichi, Japan;1. Dermatology Centre, University of Manchester, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Trust, Manchester, UK;2. Dermatology Department, York District Hospital, York, UK |
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| Abstract: | BackgroundLittle is known of the importance of chromogranins (Cg) and secretogranins (Sg) in ulcerative colitis (UC). We therefore investigated fecal levels of CgA, CgB, SgII and SgIII, and their association with inflammatory activity, disease duration and medical therapy in UC.MethodsAnalyses of CgA, CgB, SgII, SgIII and calprotectin in stool samples from 41 UC patients and 29 healthy controls were performed. Two stool samples, during relapse and remission, respectively, were obtained from each UC patient.ResultsThe levels of fecal CgA and SgII were higher in UC patients with active disease as compared to healthy controls. CgB and SgII were positively correlated with disease duration, but none of the granins were positively correlated with calprotectin, Mayo score, CRP or serum concentrations of TNF in UC patients with active disease. Also UC patients in remission had higher levels of CgA, CgB, SgII, and SgIII as compared to healthy controls. However, levels of fecal CgA, CgB, SgII and SgIII were lower during active disease relative to remission. Moreover, fecal levels of CgA and SgII were higher in UC patients in remission treated with thiopurines than in thiopurine-naïve patients in remission.ConclusionFecal chromogranins and secretogranins are increased in UC but are not associated with disease activity, but seem to increase with duration of the disease. Thus, fecal granins might reflect structural changes associated with chronicity of disease, or medical therapy. |
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